The Relationship Between Follicle-stimulating Hormone and Metabolic Dysfunction-associated Fatty Liver Disease in Men

Overview

Journal Nutr Diabetes

Specialties Endocrinology
Nutritional Sciences

Date 2024 Jul 11

PMID 38991999

Authors

Dong-Hua Bin

Fang Liu

Ke-Ping Peng

Min Zhan

Yan Tan

Qiao Liu

Wang Tang

Zeng-Nan Mo

Xiong-Jun Peng

Gui-Xiang Tian

Affiliations

Soon will be listed here.

Abstract

Objectives: The present study aimed to investigate the relationship between male hormones and metabolic dysfunction-associated fatty liver disease (MAFLD) in males.

Methods: Data from the Fangchenggang Area Male Health and Examination Survey (FAMHES) were used to analyze the male hormone levels between MAFLD patients and controls. Univariate and multivariate logistic regression analyses were performed to identify risk factors for MAFLD. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of male hormones for MAFLD.

Result: A total of 1578 individuals were included, with 482 individuals (30.54%) of MAFLD, including 293 (18.57%) with mild disease and 189 (11.98%) with moderate-to-severe disease. The MAFLD patients were significantly older than those without MAFLD. The LH, FSH, and SHBG levels in the MAFLD patients were significantly greater than those in the control group. Age, FSH, LH, SHBG, and estradiol were all risk factors for MAFLD. Age, FSH, and LH were risk factors for moderate-to-severe MAFLD. FSH was an independent risk factor for MAFLD and moderate-to-severe MAFLD. FSH showed an excellent diagnostic value, with an AUC of 0.992 alone and 0.996 after adjusting age.

Conclusions: Our findings indicate that FSH may be a potential diagnostic and predictive biomarker for MAFLD.

References

Yang L, Zhou J, Zheng Y, Hu X, He Z, Du L . Association of non-alcoholic fatty liver disease with total testosterone in non-overweight/obese men with type 2 diabetes mellitus. J Endocrinol Invest. 2023; 46(8):1565-1572. DOI: 10.1007/s40618-023-02006-6. View

Eslam M, Sanyal A, George J . MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease. Gastroenterology. 2020; 158(7):1999-2014.e1. DOI: 10.1053/j.gastro.2019.11.312. View

Lotti F, Corona G, Degli Innocenti S, Filimberti E, Scognamiglio V, Vignozzi L . Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples. Andrology. 2013; 1(2):229-39. DOI: 10.1111/j.2047-2927.2012.00031.x. View

Griswold M . The central role of Sertoli cells in spermatogenesis. Semin Cell Dev Biol. 1998; 9(4):411-6. DOI: 10.1006/scdb.1998.0203. View

Apostolov R, Wong D, Low E, Vaz K, Spurio J, Worland T . Testosterone is lower in men with non-alcoholic fatty liver disease and alcohol-related cirrhosis and is associated with adverse clinical outcomes. Scand J Gastroenterol. 2023; 58(11):1328-1334. DOI: 10.1080/00365521.2023.2220857. View

Bertone-Johnson E, Virtanen J, Niskanen L, Nurmi T, Ronkainen K, Voutilainen S . Association of follicle-stimulating hormone levels and risk of type 2 diabetes in older postmenopausal women. Menopause. 2017; 24(7):796-802. DOI: 10.1097/GME.0000000000000834. View

Saadeh S, Younossi Z, Remer E, Gramlich T, Ong J, Hurley M . The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002; 123(3):745-50. DOI: 10.1053/gast.2002.35354. View

Wang N, Li Q, Han B, Chen Y, Zhu C, Chen Y . Follicle-stimulating hormone is associated with non-alcoholic fatty liver disease in Chinese women over 55 years old. J Gastroenterol Hepatol. 2015; 31(6):1196-202. DOI: 10.1111/jgh.13271. View

Qiao S, Alasmi S, Wyatt A, Wartenberg P, Wang H, Candlish M . Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice. Nat Commun. 2023; 14(1):1098. PMC: 9968338. DOI: 10.1038/s41467-023-36681-z. View

10.

Sermondade N, Faure C, Fezeu L, Shayeb A, Bonde J, Jensen T . BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update. 2012; 19(3):221-31. PMC: 3621293. DOI: 10.1093/humupd/dms050. View

11.

De Herdt C, De Block C, Francque S, Verrijken A, Van Dessel K, Van Gaal L . A cross-sectional analysis of the association between testosterone and biopsy-proven non-alcoholic fatty liver disease in men with obesity. Endocrine. 2023; 80(1):54-63. DOI: 10.1007/s12020-022-03245-y. View

12.

Cao W, Xu Y, Shen Y, Wang Y, Ma X, Bao Y . Associations between sex hormones and metabolic-associated fatty liver disease in a middle-aged and elderly community. Endocr J. 2022; 69(8):1007-1014. DOI: 10.1507/endocrj.EJ21-0559. View

13.

Qin X, Lv H, Mo Z, Chen Z, Lin L, Peng T . Reference intervals for serum sex hormones in Han Chinese adult men from the Fangchenggang Area Male Health and Examination Survey. Clin Lab. 2012; 58(3-4):281-90. View

14.

Fouda S, Pappachan J . Metabolic-Associated Fatty Liver Disease: A Disastrous Human Health Challenge. Endocrinol Metab Clin North Am. 2023; 52(3):xv-xvi. DOI: 10.1016/j.ecl.2023.03.001. View

15.

Meziri M, Pereira W, Abdelwahab A, Degott C, Laugier P . In vitro chronic hepatic disease characterization with a multiparametric ultrasonic approach. Ultrasonics. 2005; 43(5):305-13. DOI: 10.1016/j.ultras.2004.09.002. View

16.

Burra P, Bizzaro D, Gonta A, Shalaby S, Gambato M, Morelli M . Clinical impact of sexual dimorphism in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Liver Int. 2021; 41(8):1713-1733. DOI: 10.1111/liv.14943. View

17.

Fouda S, Jeeyavudeen M, Pappachan J, Jayanthi V . Pathobiology of Metabolic-Associated Fatty Liver Disease. Endocrinol Metab Clin North Am. 2023; 52(3):405-416. DOI: 10.1016/j.ecl.2023.01.001. View

18.

Salvio G, Ciarloni A, Cutini M, Delli Muti N, Finocchi F, Perrone M . Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy. Int J Mol Sci. 2022; 23(10). PMC: 9143238. DOI: 10.3390/ijms23105497. View

19.

Oduwole O, Huhtaniemi I, Misrahi M . The Roles of Luteinizing Hormone, Follicle-Stimulating Hormone and Testosterone in Spermatogenesis and Folliculogenesis Revisited. Int J Mol Sci. 2021; 22(23). PMC: 8658012. DOI: 10.3390/ijms222312735. View

20.

Younossi Z, Koenig A, Abdelatif D, Fazel Y, Henry L, Wymer M . Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2015; 64(1):73-84. DOI: 10.1002/hep.28431. View