Association Between Non-high-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Ratio (NHHR) and Kidney Stone: Evidence from NHANES 2007-2018

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2024 Jul 8

PMID 38978025

Authors

Tao Chen

Yu Cheng

Zheng Song

Gan Zhang

Tao Zeng

Haichao Chao

Affiliations

Soon will be listed here.

Abstract

Background: As an innovative lipid parameter, NHHR (the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol) can serve as a valuable tool for assessing cardiovascular disease risk. Nevertheless, the relationship between NHHR and the risk of kidney stones remains unexplored.

Methods: A cross-sectional survey utilized data from the National Health and Population Survey (NHANES) database in the United States spanning from 2007 to 2018. Distinct statistical analyses were applied, including weighted logistic regression, stratified and interaction analysis and restricted cubic spline curve (RCS) models, to examine the correlation between NHHR and the incidence of kidney stones.

Results: This analysis encompassed 24,664 participants, with 9.63% reporting incidents of kidney stones. Following multivariate logistic regression and comprehensive adjustments, participants in NHHR quartile 4 (OR 1.34; 95% CI 1.12, 1.60, P < 0.01) exhibited a significantly increased risk of kidney stones compared to those in NHHR quartile 1 (Q1). The RCS result further illustrated a non-linear correlation between NHHR and the incidence of kidney stones. The result of subgroup analysis manifested that participants without diabetes had a higher risk of kidney stones when measured high NHHR levels compared those with diabetes (p for interaction < 0.05).

Conclusion: Elevated NHHR levels were found to be associated with an increased risk of kidney stones. Based on these findings, NHHR appears to be a promising predictive indicator for the occurrence of kidney stones.

Citing Articles

Systemic inflammation partially mediates the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and chronic cough.

Wang C, Liao X, Chen J, Lan Y, Wen J Lipids Health Dis. 2025; 24(1):85.

PMID: 40050896 PMC: 11884164. DOI: 10.1186/s12944-025-02498-6.

Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018.

Huang D, He Y Front Endocrinol (Lausanne). 2025; 16:1503780.

PMID: 40007809 PMC: 11851024. DOI: 10.3389/fendo.2025.1503780.

Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality among hypertension patients.

Su X, Rao H, Zhao C, Wu J, Zhang X, Li D Sci Rep. 2025; 15(1):6012.

PMID: 39972003 PMC: 11839901. DOI: 10.1038/s41598-025-88539-7.

Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones.

Takata T, Inoue S, Kunii K, Masauji T, Moriya J, Motoo Y Diseases. 2025; 13(1).

PMID: 39851471 PMC: 11764404. DOI: 10.3390/diseases13010007.

The correlation between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) with non-alcoholic fatty liver disease: an analysis of the population-based NHANES (2017-2018).

Yang Y, Li S, An Z, Li S Front Med (Lausanne). 2024; 11:1477820.

PMID: 39582979 PMC: 11581862. DOI: 10.3389/fmed.2024.1477820.

References

Geiss L, Wang J, Cheng Y, Thompson T, Barker L, Li Y . Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 years, United States, 1980-2012. JAMA. 2014; 312(12):1218-26. DOI: 10.1001/jama.2014.11494. View

Kittanamongkolchai W, Vaughan L, Enders F, Dhondup T, Mehta R, Krambeck A . The Changing Incidence and Presentation of Urinary Stones Over 3 Decades. Mayo Clin Proc. 2018; 93(3):291-299. PMC: 5849397. DOI: 10.1016/j.mayocp.2017.11.018. View

Cohen A, Adamsky M, Nottingham C, Pruitt J, Lapin B, Wang C . Impact of Statin Intake on Kidney Stone Formation. Urology. 2018; 124:57-61. DOI: 10.1016/j.urology.2018.01.029. View

Yuan S, Larsson S . Assessing causal associations of obesity and diabetes with kidney stones using Mendelian randomization analysis. Mol Genet Metab. 2021; 134(1-2):212-215. DOI: 10.1016/j.ymgme.2021.08.010. View

Taguchi K, Hamamoto S, Okada A, Unno R, Kamisawa H, Naiki T . Genome-Wide Gene Expression Profiling of Randall's Plaques in Calcium Oxalate Stone Formers. J Am Soc Nephrol. 2016; 28(1):333-347. PMC: 5198277. DOI: 10.1681/ASN.2015111271. View

Lee M, Hsu Y, Sung H, Wen Y, Wei L, Huang C . Low Aerobic Capacity Accelerates Lipid Accumulation and Metabolic Abnormalities Caused by High-Fat Diet-Induced Obesity in Postpartum Mice. Nutrients. 2022; 14(18). PMC: 9502809. DOI: 10.3390/nu14183746. View

Bluher M . Metabolically Healthy Obesity. Endocr Rev. 2020; 41(3). PMC: 7098708. DOI: 10.1210/endrev/bnaa004. View

Bleich S, Wang Y, Wang Y, Gortmaker S . Increasing consumption of sugar-sweetened beverages among US adults: 1988-1994 to 1999-2004. Am J Clin Nutr. 2008; 89(1):372-81. DOI: 10.3945/ajcn.2008.26883. View

Iannuzzi A, Giallauria F, Gentile M, Rubba P, Covetti G, Bresciani A . Association between Non-HDL-C/HDL-C Ratio and Carotid Intima-Media Thickness in Post-Menopausal Women. J Clin Med. 2022; 11(1). PMC: 8745439. DOI: 10.3390/jcm11010078. View

10.

Zhao W, Gong W, Wu N, Li Y, Ye K, Lu B . Association of lipid profiles and the ratios with arterial stiffness in middle-aged and elderly Chinese. Lipids Health Dis. 2014; 13:37. PMC: 4234125. DOI: 10.1186/1476-511X-13-37. View

11.

Gianfrancesco M, Paquot N, Piette J, Legrand-Poels S . Lipid bilayer stress in obesity-linked inflammatory and metabolic disorders. Biochem Pharmacol. 2018; 153:168-183. DOI: 10.1016/j.bcp.2018.02.022. View

12.

Di X, Liu S, Xiang L, Jin X . Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018. Front Immunol. 2023; 14:1116224. PMC: 9989007. DOI: 10.3389/fimmu.2023.1116224. View

13.

Sheng G, Liu D, Kuang M, Zhong Y, Zhang S, Zou Y . Utility of Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio in Evaluating Incident Diabetes Risk. Diabetes Metab Syndr Obes. 2022; 15:1677-1686. PMC: 9166911. DOI: 10.2147/DMSO.S355980. View

14.

Torricelli F, De S, Gebreselassie S, Li I, Sarkissian C, Monga M . Dyslipidemia and kidney stone risk. J Urol. 2013; 191(3):667-72. DOI: 10.1016/j.juro.2013.09.022. View

15.

Huang Y, Gao L, Cheng H, Wang X, Dong H, Yan Y . Difference of glucose and lipid metabolism abnormalities and body fat between the Chinese and USA teenagers. J Glob Health. 2023; 13:04041. PMC: 10193895. DOI: 10.7189/jogh.13.04041. View

16.

Klop B, Elte J, Cabezas M . Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013; 5(4):1218-40. PMC: 3705344. DOI: 10.3390/nu5041218. View

17.

Lin B, Huang R, Lin B, Hong Y, Lin M, He X . Associations between nephrolithiasis and diabetes mellitus, hypertension and gallstones: A meta-analysis of cohort studies. Nephrology (Carlton). 2020; 25(9):691-699. DOI: 10.1111/nep.13740. View

18.

Song W, Hu H, Ni J, Zhang H, Zhang H, Yang G . The relationship between ethylene oxide levels in hemoglobin and the prevalence of kidney stones in US adults: an exposure-response analysis from NHANES 2013-2016. Environ Sci Pollut Res Int. 2022; 30(10):26357-26366. DOI: 10.1007/s11356-022-24086-2. View

19.

Lin D, Qi Y, Huang C, Wu M, Wang C, Li F . Associations of lipid parameters with insulin resistance and diabetes: A population-based study. Clin Nutr. 2017; 37(4):1423-1429. DOI: 10.1016/j.clnu.2017.06.018. View

20.

Khan S, Canales B, Dominguez-Gutierrez P . Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation. Nat Rev Nephrol. 2021; 17(6):417-433. DOI: 10.1038/s41581-020-00392-1. View