» Articles » PMID: 24555711

Association of Lipid Profiles and the Ratios with Arterial Stiffness in Middle-aged and Elderly Chinese

Overview
Publisher Biomed Central
Date 2014 Feb 22
PMID 24555711
Citations 46
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Serum lipids and the ratios are known to be associated with the cardiovascular diseases (CVD). However, the associations of serum lipids and the ratios related to arterial stiffness are unclear. We sought to compare the strength of these serum lipids and the ratios with arterial stiffness assessing by brachial-ankle pulse wave velocity (baPWV) in the middle-aged and elderly Chinese subjects.

Methods: A total number of 1133 Chinese aged from 50 to 90 years old were recruited from Shanghai downtown district. The serum lipids, baPWV and major cardiovascular risk factors of the participants were measured.

Results: Participants with high baPWV exhibited higher levels of non-HDL-c, TC/HDL-c, TG/HDL-c, LDL-c/HDL-c, and non-HDL-c/HDL-c, while HDL-c worked in the opposite direction (all P<0.05). In addition, TC, TG, LDL-c, non-HDL-c, TC/HDL-c, TG/HDL-c, LDL-c/HDL-c, and non-HDL-c/HDL-c had a positive relationship with the baPWV value, while HDL-c was on the contrary (all P <0.05). Finally, individuals with high non-HDL-c/HDL-c (OR 1.71, 95% CI 1.06-2.55, P = 0.013) and low HDL-c (OR 0.57, 95% CI 0.35-0.96, P = 0.024) were seem to be at high risk of arterial stiffness.

Conclusions: As a risk indicator, non-HDL-c/HDL-c, which could be readily obtained from routine serum lipids, was significantly associated with baPWV. Non-HDL-c/HDL-c was superior to traditional lipid variables for estimating arterial stiffness in the middle-aged and elderly Chinese population.

Citing Articles

Serum lipid profiling reveals characteristic lipid signatures associated with stroke in patients with leukoaraiosis.

Lin F, Song Y, Cao H, Liao F, Deng Y, Wei Q Sci Rep. 2024; 14(1):31337.

PMID: 39733101 PMC: 11682383. DOI: 10.1038/s41598-024-82808-7.


Association of cumulative non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with the risk of cardiometabolic disease.

Liu L, Liu S, Liao Y, Zhang X, Wang M, Lin L Front Cardiovasc Med. 2024; 11:1500025.

PMID: 39635266 PMC: 11614763. DOI: 10.3389/fcvm.2024.1500025.


Novel non-HDLc/HDLc ratio for predicting MASLD: a cross-sectional study in a Chinese health screening population.

Hong Y, Chen X, Yuan H, Huang Z, Tao S, Xie F BMC Gastroenterol. 2024; 24(1):439.

PMID: 39609681 PMC: 11603918. DOI: 10.1186/s12876-024-03525-z.


Association of non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) with gout prevalence: a cross-sectional study.

Guo X, Chu H, Xu H, Wang S, He J, Wang Y Front Nutr. 2024; 11:1480689.

PMID: 39512523 PMC: 11541233. DOI: 10.3389/fnut.2024.1480689.


Development of a comprehensive risk prediction model for arterial stiffness assessment in individuals with obesity.

Pescari D, Borlea A, Mihuta S, Stoian D Front Med (Lausanne). 2024; 11:1430437.

PMID: 39224613 PMC: 11368134. DOI: 10.3389/fmed.2024.1430437.


References
1.
Brinkley T, Nicklas B, Kanaya A, Satterfield S, Lakatta E, Simonsick E . Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study. Hypertension. 2009; 53(5):846-52. PMC: 2692957. DOI: 10.1161/HYPERTENSIONAHA.108.127043. View

2.
McQueen M, Hawken S, Wang X, Ounpuu S, Sniderman A, Probstfield J . Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study. Lancet. 2008; 372(9634):224-33. DOI: 10.1016/S0140-6736(08)61076-4. View

3.
Hosseini-Esfahani F, Mousavi Nasl Khameneh A, Mirmiran P, Ghanbarian A, Azizi F . Trends in risk factors for cardiovascular disease among Iranian adolescents: the Tehran Lipid and Glucose Study, 1999-2008. J Epidemiol. 2011; 21(5):319-28. PMC: 3899430. DOI: 10.2188/jea.JE20100162. View

4.
Mattace-Raso F, van der Cammen T, Hofman A, van Popele N, Bos M, Schalekamp M . Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006; 113(5):657-63. DOI: 10.1161/CIRCULATIONAHA.105.555235. View

5.
Wang F, Ye P, Luo L, Xiao W, Qi L, Bian S . Association of serum lipids with arterial stiffness in a population-based study in Beijing. Eur J Clin Invest. 2011; 41(9):929-36. DOI: 10.1111/j.1365-2362.2011.02481.x. View