A Case of Pulmonary Infection in a Patient with Acute Myeloid Leukemia
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  Abstract
            An elderly woman with a history of myelodysplastic syndrome complicated by cavitary pneumonia treated with antibiotics and antifungal therapy was admitted with severe sepsis and pulmonary opacities on imaging. Pulmonary infection with , was diagnosed on bronchopulmonary lavage (BAL). This common environmental fungus is known to cause rare but severe infection in immunocompromised hosts. The patient was diagnosed with progression to acute myeloid leukemia during the hospitalization for which chemotherapy was initiated. Despite broadening antifungal therapy, the patient developed multi-organ system failure and died.
  References
                              1.
  
    Meletiadis J, Mouton J, Meis J, Verweij P
    
    . Combination chemotherapy for the treatment of invasive infections by Scedosporium prolificans. Clin Microbiol Infect. 2001; 6(6):336-7.
    
          DOI: 10.1046/j.1469-0691.2000.00089.x.
    
    View
  
2.
  
    Troke P, Aguirrebengoa K, Arteaga C, Ellis D, Heath C, Lutsar I
    
    . Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients. Antimicrob Agents Chemother. 2008; 52(5):1743-50.
          PMC: 2346616.
    
          DOI: 10.1128/AAC.01388-07.
    
    View
  
3.
  
    Jenks J, Seidel D, Cornely O, Chen S, Van Hal S, Kauffman C
    
    . Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008-2019. Clin Microbiol Infect. 2020; 26(6):784.e1-784.e5.
    
          DOI: 10.1016/j.cmi.2020.01.012.
    
    View
  
4.
  
    Tong S, Peleg A, Yoong J, Handke R, Szer J, Slavin M
    
    . Breakthrough Scedosporium prolificans infection while receiving voriconazole prophylaxis in an allogeneic stem cell transplant recipient. Transpl Infect Dis. 2007; 9(3):241-3.
    
          DOI: 10.1111/j.1399-3062.2007.00203.x.
    
    View
  
5.
  
    Neoh C, Chen S, Crowe A, Hamilton K, Nguyen Q, Marriott D
    
    . Invasive  and  Infections in Australia: A Multicenter Retrospective Cohort Study. Open Forum Infect Dis. 2023; 10(2):ofad059.
          PMC: 9970007.
    
          DOI: 10.1093/ofid/ofad059.
    
    View