Effects of Haskap ( L.) Extracts Against Oxidative Stress and Inflammation in RAW 264.7 Cells

Overview

Journal Prev Nutr Food Sci

Date 2024 Jul 8

PMID 38974596

Authors

Chong Li

Jeong Hyeon Kang

Kyung Im Jung

Mi Hwa Park

Mihyang Kim

Affiliations

Soon will be listed here.

Abstract

This study aimed to evaluate the antioxidant and anti-inflammatory activities of L. ethanol extract (LCEE) and water extract (LCWE) . We primarily evaluated the improvement effect of LCWE and LCEE on hydrogen peroxide (HO)-induced oxidative damage and lipopolysaccharide (LPS)-induced inflammatory damage in RAW 264.7 cells by detecting oxidation-related indicators and inflammatory factors, respectively. Cellular studies showed that LCWE and LCEE increased superoxide dismutase and catalase antioxidant enzyme levels and decreased malondialdehyde and nitric oxide peroxide levels in HO-induced RAW 264.7 cells. Moreover, LCWE and LCEE decreased the secretion of inflammatory factors [e.g., interleukin (IL)-6, IL-1β, and tumor necrosis factor-α] in LPS-induced RAW 264.7 cells. In conclusion, LCWE and LCEE demonstrated excellent antioxidant and anti-inflammatory effects . However, LCWE was superior to LCEE, which may be related to its chemical composition and requires further research.

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