Poly(-coumaric Acid) Nanoparticles Alleviate Temporomandibular Joint Osteoarthritis by Inhibiting Chondrocyte Ferroptosis

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2024 Jul 8

PMID 38973989

Authors

Jiaxin Guo

Kai Su

Liying Wang

Bingyu Feng

Xinru You

Miao Deng

Wei Seong Toh

Jun Wu

Bin Cheng

Juan Xia

Affiliations

Soon will be listed here.

Abstract

Oxidative stress and inflammation are key drivers of osteoarthritis (OA) pathogenesis and disease progression. Herein we report the synthesis of poly(-coumaric) nanoparticles (PCA NPs) from -courmaic acid (-CA), a naturally occurring phytophenolic acid, to be a multifunctional and drug-free therapeutic for temporomandibular joint osteoarthritis (TMJOA). Compared to hyaluronic acid (HA) that is clinically given as viscosupplementation, PCA NPs exhibited long-term efficacy, superior anti-oxidant and anti-inflammatory properties in alleviating TMJOA and repairing the TMJ cartilage and subchondral bone in a rat model of TMJOA. Notably, TMJ repair mediated by PCA NPs could be attributed to their anti-oxidant and anti-inflammatory properties in enhancing cell proliferation and matrix synthesis, while reducing inflammation, oxidative stress, matrix degradation, and chondrocyte ferroptosis. Overall, our study demonstrates a multifunctional nanoparticle, synthesized from natural -coumaric acid, that is stable and possess potent antioxidant, anti-inflammatory properties and ferroptosis inhibition, beneficial for treatment of TMJOA.

Citing Articles

Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review.

Bertolucci V, Ninomiya A, Longato G, Kaneko L, Nonose N, Scariot P Antioxidants (Basel). 2025; 14(1).

PMID: 39857415 PMC: 11762496. DOI: 10.3390/antiox14010081.

Green Synthesis of Silver Oxide Nanoparticles from Fruit Extract: Characterization and Bioactivity Assessment.

Zuniga-Miranda J, Vaca-Vega D, Vizuete K, Carrera-Pacheco S, Gonzalez-Pastor R, Heredia-Moya J Nanomaterials (Basel). 2024; 14(23).

PMID: 39683263 PMC: 11643947. DOI: 10.3390/nano14231875.

Bioactive Compounds and Their Chondroprotective Effects for Osteoarthritis Amelioration: A Focus on Nanotherapeutic Strategies, Epigenetic Modifications, and Gut Microbiota.

Hridayanka K, Duttaroy A, Basak S Nutrients. 2024; 16(21).

PMID: 39519419 PMC: 11547880. DOI: 10.3390/nu16213587.

Inhalable and bioactive lipid-nanomedicine based on bergapten for targeted acute lung injury therapy via orchestrating macrophage polarization.

Liao R, Sun Z, Wang L, Xian C, Lin R, Zhuo G Bioact Mater. 2024; 43:406-422.

PMID: 39411684 PMC: 11474395. DOI: 10.1016/j.bioactmat.2024.09.020.

References

Bolduc J, Collins J, Loeser R . Reactive oxygen species, aging and articular cartilage homeostasis. Free Radic Biol Med. 2018; 132:73-82. PMC: 6342625. DOI: 10.1016/j.freeradbiomed.2018.08.038. View

Kilic I, Yesiloglu Y . Spectroscopic studies on the antioxidant activity of p-coumaric acid. Spectrochim Acta A Mol Biomol Spectrosc. 2013; 115:719-24. DOI: 10.1016/j.saa.2013.06.110. View

Kang R, Kroemer G, Tang D . The tumor suppressor protein p53 and the ferroptosis network. Free Radic Biol Med. 2018; 133:162-168. PMC: 6251771. DOI: 10.1016/j.freeradbiomed.2018.05.074. View

Deng L, He S, Guo N, Tian W, Zhang W, Luo L . Molecular mechanisms of ferroptosis and relevance to inflammation. Inflamm Res. 2022; 72(2):281-299. PMC: 9762665. DOI: 10.1007/s00011-022-01672-1. View

Gupta R, Lall R, Srivastava A, Sinha A . Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019; 6:192. PMC: 6603175. DOI: 10.3389/fvets.2019.00192. View

Yao X, Sun K, Yu S, Luo J, Guo J, Lin J . Chondrocyte ferroptosis contribute to the progression of osteoarthritis. J Orthop Translat. 2020; 27:33-43. PMC: 7750492. DOI: 10.1016/j.jot.2020.09.006. View

Huang X, You Y, Xi Y, Ni B, Chu X, Zhang R . p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes. Inflammation. 2019; 43(2):619-628. DOI: 10.1007/s10753-019-01142-7. View

Zhang S, Teo K, Chuah S, Lai R, Lim S, Toh W . MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis. Biomaterials. 2019; 200:35-47. DOI: 10.1016/j.biomaterials.2019.02.006. View

Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M . Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Signal Transduct Target Ther. 2023; 8(1):56. PMC: 9898571. DOI: 10.1038/s41392-023-01330-w. View

10.

Cao J, Dixon S . Mechanisms of ferroptosis. Cell Mol Life Sci. 2016; 73(11-12):2195-209. PMC: 4887533. DOI: 10.1007/s00018-016-2194-1. View

11.

Zhang S, Xu J, Si H, Wu Y, Zhou S, Shen B . The Role Played by Ferroptosis in Osteoarthritis: Evidence Based on Iron Dyshomeostasis and Lipid Peroxidation. Antioxidants (Basel). 2022; 11(9). PMC: 9495695. DOI: 10.3390/antiox11091668. View

12.

Li L, Sun S, Tan L, Wang Y, Wang L, Zhang Z . Polystyrene Nanoparticles Reduced ROS and Inhibited Ferroptosis by Triggering Lysosome Stress and TFEB Nucleus Translocation in a Size-Dependent Manner. Nano Lett. 2019; 19(11):7781-7792. DOI: 10.1021/acs.nanolett.9b02795. View

13.

Ren B, Kwah M, Liu C, Ma Z, Shanmugam M, Ding L . Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Lett. 2021; 515:63-72. DOI: 10.1016/j.canlet.2021.05.001. View

14.

Lane R, Fu Y, Matsuzaki S, Kinter M, Humphries K, Griffin T . Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Ther. 2015; 17:54. PMC: 4384316. DOI: 10.1186/s13075-015-0566-9. View

15.

Barry F, Chai F, Chijcheapaza-Flores H, Garcia-Fernandez M, Blanchemain N, Nicot R . Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis. J Stomatol Oral Maxillofac Surg. 2021; 123(5):e336-e341. DOI: 10.1016/j.jormas.2021.08.003. View

16.

Doll S, Proneth B, Tyurina Y, Panzilius E, Kobayashi S, Ingold I . ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2016; 13(1):91-98. PMC: 5610546. DOI: 10.1038/nchembio.2239. View

17.

Brown S, Kumar S, Sharma B . Intra-articular targeting of nanomaterials for the treatment of osteoarthritis. Acta Biomater. 2019; 93:239-257. PMC: 6615949. DOI: 10.1016/j.actbio.2019.03.010. View

18.

Li N, Wang W, Zhou H, Wu Q, Duan M, Liu C . Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med. 2020; 160:303-318. DOI: 10.1016/j.freeradbiomed.2020.08.009. View

19.

Barnett R . Osteoarthritis. Lancet. 2018; 391(10134):1985. DOI: 10.1016/S0140-6736(18)31064-X. View

20.

Ren J, Li C, Yan X, Qu Y, Yang Y, Guo Z . Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms. Oxid Med Cell Longev. 2021; 2021:6643382. PMC: 8133868. DOI: 10.1155/2021/6643382. View