Induction of Protective Immunity to Plasmodium Falciparum in Saimiri Sciureus Monkeys with Partially Purified Exoantigens

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1985 Sep 1

PMID 3897052

Citations 9

Authors

M A James

I Kakoma

M Ristic

M Cagnard

Affiliations

Soon will be listed here.

Abstract

Soluble Plasmodium falciparum exoantigens in crude culture supernatant fluids induced protective immunity against experimental falciparum malaria in Bolivian Saimiri sciureus monkeys. Susceptible squirrel monkeys were vaccinated with an aluminum hydroxide-fortified fraction purified from culture supernatants of P. falciparum Indochina I and Geneve/SGE-1 by cation-exchange (sulfopropyl-trisacryl) chromatography. Animals immunized with sulfopropyl-purified and corresponding control immunogens were challenged with whole blood containing monkey-adapted virulent organisms of the Indochina I strain. Hematological, serological, and parasitological profiles, including the appearance of crisis forms, served as potential indicators of protection. This immunogen conferred significant clinical protection of squirrel monkeys against needle challenge with the homologous Indochina I strain and a moderate degree of heterologous strain immunity.

Citing Articles

IgG subclass responses to excreted-secreted antigens of Plasmodium falciparum in a low-transmission malaria area of the Peruvian Amazon.

Saavedra-Langer R, Marapara J, Valle-Campos A, Durand S, Vasquez-Chasnamote M, Silva H Malar J. 2018; 17(1):328.

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Detection of Signal Regulatory Protein α in (Squirrel Monkey) by Anti-Human Monoclonal Antibody.

de Souza H, Costa-Correa E, Bianco-Junior C, Andrade M, Lima-Junior J, Pratt-Riccio L Front Immunol. 2018; 8:1814.

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On Programmed Cell Death in Plasmodium falciparum: Status Quo.

Engelbrecht D, Durand P, Coetzer T J Trop Med. 2012; 2012:646534.

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Immunogenicity and antigenic reactivity of a carrier-free synthetic peptide complex derived from a 70-kDa Plasmodium falciparum exoantigen.

James M, Montenegro-James S Parasitol Res. 1993; 79(6):501-7.

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Long-term protection of squirrel monkeys (Saimiri sciureus) against Plasmodium falciparum challenge inoculations after various time intervals.

Roussilhon C, Fandeur T, Dedet J Parasitol Res. 1988; 75(2):118-22.

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