Experimental Study Using Phantom Models of Cerebral Aneurysms and 4D-DSA to Measure Blood Flow on 3D-color-coded Images

Overview

Journal Technol Health Care

Publisher Sage Publications

Specialties Biomedical Engineering
Biotechnology
Health Services

Date 2024 Jul 5

PMID 38968064

Authors

Soichiro Fujimura

Yuma Yamanaka

Issei Kan

Masahiro Nagao

Katharina Otani

Kostadin Karagiozov

Koji Fukudome

Toshihiro Ishibashi

Hiroyuki Takao

Masahiro Motosuke

Makoto Yamamoto

Yuichi Murayama

Affiliations

Soon will be listed here.

Abstract

Background: The current 3D-iFlow application can only measure the arrival time of contrast media through intensity values. If the flow rate could be estimated by 3D-iFlow, patient-specific hemodynamics could be determined within the scope of normal diagnostic management, eliminating the need for additional resources for blood flow rate estimation.

Objective: The aim of this study is to develop and validate a method for measuring the flow rate by data obtained from 3D-iFlow images - a prototype application in Four-dimensional digital subtraction angiography (4D-DSA).

Methods: Using phantom model and experimental circuit with circulating glycerin solution, an equation for the relationship between contrast media intensity and flow rate was developed. Applying the equation to the aneurysm phantom models, the derived flow rate was evaluated.

Results: The average errors between the derived flow rate and setting flow rate became larger when the glycerin flow and the X-rays from the X-ray tube of the angiography system were parallel to each other or when the measurement point included overlaps with other contrast enhanced areas.

Conclusion: Although the error increases dependent on the imaging direction and overlap of contrast enhanced area, the developed equation can estimate the flow rate using the image intensity value measured on 3D-iFlow based on 4D-DSA.

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