Hydrogel-Encapsulated Pancreatic Islet Cells As a Promising Strategy for Diabetic Cell Therapy

Overview

Journal Research (Wash D C)

Specialty Biology

Date 2024 Jul 5

PMID 38966749

Authors

Zhikun Huan

Jingbo Li

Zhiqiang Luo

Yunru Yu

Ling Li

Affiliations

Soon will be listed here.

Abstract

Islet transplantation has now become a promising treatment for insulin-deficient diabetes mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous insulin supplementation, but its large-scale clinical application is impeded by donor shortages, immune rejection, and unsuitable transplantation sites. To overcome these challenges, an increasing number of studies have attempted to transplant hydrogel-encapsulated islet cells to treat diabetes. This review mainly focuses on the strategy of hydrogel-encapsulated pancreatic islet cells for diabetic cell therapy, including different cell sources encapsulated in hydrogels, encapsulation methods, hydrogel types, and a series of accessorial manners to improve transplantation outcomes. In addition, the formation and application challenges as well as prospects are also presented.

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