Accessory Cells for β-cell Transplantation
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Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycaemic alterations and life-threatening complications. Restoration of the endogenous β-cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive β-cell regeneration remain enigmatic and β-cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in β-cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.
Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy.
Huan Z, Li J, Luo Z, Yu Y, Li L Research (Wash D C). 2024; 7:0403.
PMID: 38966749 PMC: 11221926. DOI: 10.34133/research.0403.
Renewable Human Cell Model for Type 1 Diabetes Research: EndoC-H5/HUVEC Coculture Spheroids.
Porter J, Yitayew M, Tabrizian M J Diabetes Res. 2024; 2023:6610007.
PMID: 38162632 PMC: 10757655. DOI: 10.1155/2023/6610007.
Islet transplantation into brown adipose tissue can delay immune rejection.
Kepple J, Barra J, Young M, Hunter C, Tse H JCI Insight. 2022; 7(4).
PMID: 35015736 PMC: 8876467. DOI: 10.1172/jci.insight.152800.
The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity.
Ilegems E, Berggren P Front Endocrinol (Lausanne). 2021; 12:652853.
PMID: 33967961 PMC: 8104082. DOI: 10.3389/fendo.2021.652853.
Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?.
Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H Cells. 2021; 10(1).
PMID: 33477961 PMC: 7835995. DOI: 10.3390/cells10010191.