Omega-3 Polyunsatured Fatty Acids and Physical Performance Across the Lifespan: a Narrative Review

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2024 Jul 5

PMID 38966419

Authors

Domenico Azzolino

Camilla Bertoni

Valentina De Cosmi

Giulia Carla Immacolata Spolidoro

Carlo Agostoni

Tiziano Lucchi

Alessandra Mazzocchi

Affiliations

Soon will be listed here.

Abstract

Background And Aims: Physical performance is a major contributor of mobility and independence during older life. Despite a progressive decline in musculoskeletal function starts from middle age, several factors acting during the life-course can negatively influence musculoskeletal functional capacities. Lifestyle interventions incorporating nutrition and physical exercise can help maximizing the muscle functional capacities in early life as well as preserving them later in life. Among various dietary compounds, omega-3 polyunsaturated fatty acids (PUFAs) are gaining growing attention for their potential effects on muscle membrane composition and muscle function. Indeed, several pathways are enhanced, such as an attenuation of pro-inflammatory oxidative stress, mitochondrial function, activation of the mammalian target of rapamycin (mTOR) signaling and reduction of insulin resistance.

Methods: We performed a narrative review to explore the existing literature on the relationship between omega-3 PUFAs and physical performance across the life-course.

Results: Growing evidence from randomized controlled trials (RCTs) suggests beneficial effects of omega-3 PUFAs on muscle function, including physical performance parameters in mid to later life. On the other hand, despite a direct association in early life is not available in literature, some mechanisms by which omega-3 PUFAs may contribute to improved adult physical performance could be hypothesized.

Conclusion: Omega-3 PUFAs are gaining growing attention for their positive effect on muscle function parameters. The integration of physical function measures in future studies would be of great interest to explore whether omega-3 PUFAs could contribute to improved muscle function, starting from early life and extending throughout the lifespan. However, larger and high-quality RCTs are needed to fully elucidate the beneficial effects of omega-3 PUFAs supplementation on muscle mass and function.

Citing Articles

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Ali Z, Al-Ghouti M, Abou-Saleh H, Rahman M Mar Drugs. 2024; 22(10).

PMID: 39452854 PMC: 11509197. DOI: 10.3390/md22100446.

References

Guralnik J, Ferrucci L, Pieper C, Leveille S, Markides K, Ostir G . Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci. 2000; 55(4):M221-31. DOI: 10.1093/gerona/55.4.m221. View

Tseng P, Zeng B, Zeng B, Liao Y, Stubbs B, Kuo J . Omega-3 polyunsaturated fatty acids in sarcopenia management: A network meta-analysis of randomized controlled trials. Ageing Res Rev. 2023; 90:102014. DOI: 10.1016/j.arr.2023.102014. View

Troesch B, Eggersdorfer M, Laviano A, Rolland Y, Smith A, Warnke I . Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition. Nutrients. 2020; 12(9). PMC: 7551800. DOI: 10.3390/nu12092555. View

Echeverria F, Valenzuela R, Hernandez-Rodas M, Valenzuela A . Docosahexaenoic acid (DHA), a fundamental fatty acid for the brain: New dietary sources. Prostaglandins Leukot Essent Fatty Acids. 2017; 124:1-10. DOI: 10.1016/j.plefa.2017.08.001. View

Dent E, Morley J, Cruz-Jentoft A, Arai H, Kritchevsky S, Guralnik J . International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. J Nutr Health Aging. 2018; 22(10):1148-1161. DOI: 10.1007/s12603-018-1139-9. View

Robinson S, Simmonds S, Jameson K, Syddall H, Dennison E, Cooper C . Muscle strength in older community-dwelling men is related to type of milk feeding in infancy. J Gerontol A Biol Sci Med Sci. 2012; 67(9):990-6. DOI: 10.1093/gerona/gls061. View

Brenna J, Diau G . The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. Prostaglandins Leukot Essent Fatty Acids. 2007; 77(5-6):247-50. PMC: 2174532. DOI: 10.1016/j.plefa.2007.10.016. View

Kuh D, Hardy R, Butterworth S, Okell L, Wadsworth M, Cooper C . Developmental origins of midlife grip strength: findings from a birth cohort study. J Gerontol A Biol Sci Med Sci. 2006; 61(7):702-6. DOI: 10.1093/gerona/61.7.702. View

Cornish S, Cordingley D, Shaw K, Forbes S, Leonhardt T, Bristol A . Effects of Omega-3 Supplementation Alone and Combined with Resistance Exercise on Skeletal Muscle in Older Adults: A Systematic Review and Meta-Analysis. Nutrients. 2022; 14(11). PMC: 9182791. DOI: 10.3390/nu14112221. View

10.

Agostoni C, Nobile M, Ciappolino V, Delvecchio G, Tesei A, Turolo S . The Role of Omega-3 Fatty Acids in Developmental Psychopathology: A Systematic Review on Early Psychosis, Autism, and ADHD. Int J Mol Sci. 2017; 18(12). PMC: 5751211. DOI: 10.3390/ijms18122608. View

11.

Murray G, Veijola J, Moilanen K, Miettunen J, Glahn D, Cannon T . Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort study. J Child Psychol Psychiatry. 2006; 47(1):25-9. DOI: 10.1111/j.1469-7610.2005.01450.x. View

12.

Thielecke F, Blannin A . Omega-3 Fatty Acids for Sport Performance-Are They Equally Beneficial for Athletes and Amateurs? A Narrative Review. Nutrients. 2020; 12(12). PMC: 7760705. DOI: 10.3390/nu12123712. View

13.

Nevins J, Donovan S, Snetselaar L, Dewey K, Novotny R, Stang J . Omega-3 Fatty Acid Dietary Supplements Consumed During Pregnancy and Lactation and Child Neurodevelopment: A Systematic Review. J Nutr. 2021; 151(11):3483-3494. PMC: 8764572. DOI: 10.1093/jn/nxab238. View

14.

Calvani R, Marini F, Cesari M, Buford T, Manini T, Pahor M . Systemic inflammation, body composition, and physical performance in old community-dwellers. J Cachexia Sarcopenia Muscle. 2016; 8(1):69-77. PMC: 5326820. DOI: 10.1002/jcsm.12134. View

15.

Phillips N, Gray S, Combet E, Witard O . Long-chain n -3 polyunsaturated fatty acids for the management of age- and disease-related declines in skeletal muscle mass, strength and physical function. Curr Opin Clin Nutr Metab Care. 2023; 27(2):98-105. DOI: 10.1097/MCO.0000000000000986. View

16.

Graser J, Letsch C, van Hedel H . Reliability of timed walking tests and temporo-spatial gait parameters in youths with neurological gait disorders. BMC Neurol. 2016; 16:15. PMC: 4736644. DOI: 10.1186/s12883-016-0538-y. View

17.

Krzyminska-Siemaszko R, Czepulis N, Lewandowicz M, Zasadzka E, Suwalska A, Witowski J . The Effect of a 12-Week Omega-3 Supplementation on Body Composition, Muscle Strength and Physical Performance in Elderly Individuals with Decreased Muscle Mass. Int J Environ Res Public Health. 2015; 12(9):10558-74. PMC: 4586628. DOI: 10.3390/ijerph120910558. View

18.

Bird J, Troesch B, Warnke I, Calder P . The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: A scoping systematic review and meta-analysis. Clin Nutr ESPEN. 2021; 46:73-86. DOI: 10.1016/j.clnesp.2021.10.011. View

19.

Calder P . Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017; 45(5):1105-1115. DOI: 10.1042/BST20160474. View

20.

Hall K, Cohen H, Pieper C, Fillenbaum G, Kraus W, Huffman K . Physical Performance Across the Adult Life Span: Correlates With Age and Physical Activity. J Gerontol A Biol Sci Med Sci. 2016; 72(4):572-578. PMC: 6075535. DOI: 10.1093/gerona/glw120. View