A Prospective Longitudinal Study of Risk Factors for Abdominal Aortic Aneurysm

Overview

Journal Physiol Rep

Specialty Physiology

Date 2024 Jul 1

PMID 38946069

Authors

Benjamin S Stacey

Jun Seok Cho

Damien Laneelle

Mohammad Bashir

Ian M Williams

Michael H Lewis

Damian M Bailey

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to identify risk factors for abdominal aortic aneurysm (AAA) from the largest Welsh screening cohort to date. Patients were recruited from 1993 (to 2015) as part of the South East Wales AAA screening programme through general practitioners. Demographic data and risk factors were collected by means of a self-report questionnaire. Statistical tests were performed to determine whether associations could be observed between AAA and potential risk factors. Odds ratios (OR) were also calculated for each of the risk factors identified. A total of 6879 patients were included in the study. Two hundred and seventy-five patients (4.0%) presented with AAA, of which 16% were female and 84% were male. Patients with AAA were older than the (no AAA) control group (p < 0.0001). The following risk factors were identified for AAA: family history of AAA (p < 0.0001); history of vascular surgery (p < 0.0001), cerebrovascular accident (p < 0.0001), coronary heart disease (p < 0.0001), diabetes (p < 0.0001), medication (p = 0.0018), claudication (p < 0.0001), smoking history (p = 0.0001) and chronic obstructive pulmonary disorder (p = 0.0007). AAA is associated with classical vascular risk factors, in addition to other less-well-documented risk factors including previous vascular surgery. These findings have practical implications with the potential to improve future clinical screening of patients in order to reduce AAA mortality.

Citing Articles

A prospective longitudinal study of risk factors for abdominal aortic aneurysm.

Stacey B, Cho J, Laneelle D, Bashir M, Williams I, Lewis M Physiol Rep. 2024; 12(13):e16130.

PMID: 38946069 PMC: 11214915. DOI: 10.14814/phy2.16130.

References

Sweeting M, Thompson S, Brown L, Powell J . Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms. Br J Surg. 2012; 99(5):655-65. DOI: 10.1002/bjs.8707. View

Grootenboer N, van Sambeek M, Arends L, Hendriks J, Hunink M, Bosch J . Systematic review and meta-analysis of sex differences in outcome after intervention for abdominal aortic aneurysm. Br J Surg. 2010; 97(8):1169-79. DOI: 10.1002/bjs.7134. View

Lederle F, Nelson D, Joseph A . Smokers' relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review. J Vasc Surg. 2003; 38(2):329-34. DOI: 10.1016/s0741-5214(03)00136-8. View

Gretarsdottir S, Baas A, Thorleifsson G, Holm H, den Heijer M, de Vries J . Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010; 42(8):692-7. PMC: 4157066. DOI: 10.1038/ng.622. View

Wanhainen A, Bjorck M, Boman K, Rutegard J, Bergqvist D . Influence of diagnostic criteria on the prevalence of abdominal aortic aneurysm. J Vasc Surg. 2001; 34(2):229-35. DOI: 10.1067/mva.2001.115801. View

Clifton M . Familial abdominal aortic aneurysms. Br J Surg. 1977; 64(11):765-6. DOI: 10.1002/bjs.1800641102. View

Lederle F, Johnson G, Wilson S, Chute E, Hye R, Makaroun M . The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators. Arch Intern Med. 2000; 160(10):1425-30. DOI: 10.1001/archinte.160.10.1425. View

Svensjo S, Bjorck M, Wanhainen A . Current prevalence of abdominal aortic aneurysm in 70-year-old women. Br J Surg. 2012; 100(3):367-72. DOI: 10.1002/bjs.8984. View

Alcorn H, WOLFSON Jr S, Sutton-Tyrrell K, Kuller L, OLeary D . Risk factors for abdominal aortic aneurysms in older adults enrolled in The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 1996; 16(8):963-70. DOI: 10.1161/01.atv.16.8.963. View

10.

Golledge J, Muller J, Daugherty A, Norman P . Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol. 2006; 26(12):2605-13. DOI: 10.1161/01.ATV.0000245819.32762.cb. View

11.

Wanhainen A, Bergqvist D, Boman K, Nilsson T, Rutegard J, Bjorck M . Risk factors associated with abdominal aortic aneurysm: a population-based study with historical and current data. J Vasc Surg. 2005; 41(3):390-6. DOI: 10.1016/j.jvs.2005.01.002. View

12.

Stacey B, Cho J, Laneelle D, Bashir M, Williams I, Lewis M . A prospective longitudinal study of risk factors for abdominal aortic aneurysm. Physiol Rep. 2024; 12(13):e16130. PMC: 11214915. DOI: 10.14814/phy2.16130. View

13.

Lo R, Lu B, Fokkema M, Conrad M, Patel V, Fillinger M . Relative importance of aneurysm diameter and body size for predicting abdominal aortic aneurysm rupture in men and women. J Vasc Surg. 2014; 59(5):1209-16. PMC: 4004688. DOI: 10.1016/j.jvs.2013.10.104. View

14.

Wilmink T, Quick C, Day N . The association between cigarette smoking and abdominal aortic aneurysms. J Vasc Surg. 1999; 30(6):1099-105. DOI: 10.1016/s0741-5214(99)70049-2. View

15.

Blanchard J, Armenian H, Friesen P . Risk factors for abdominal aortic aneurysm: results of a case-control study. Am J Epidemiol. 2000; 151(6):575-83. DOI: 10.1093/oxfordjournals.aje.a010245. View

16.

Xiong J, Wu Z, Chen C, Guo W . Chronic obstructive pulmonary disease effect on the prevalence and postoperative outcome of abdominal aortic aneurysms: A meta-analysis. Sci Rep. 2016; 6:25003. PMC: 4845024. DOI: 10.1038/srep25003. View

17.

Bjorck M, Wanhainen A . Pathophysiology of AAA: heredity vs environment. Prog Cardiovasc Dis. 2013; 56(1):2-6. DOI: 10.1016/j.pcad.2013.05.003. View

18.

OKelly T, Heather B . General practice-based population screening for abdominal aortic aneurysms: a pilot study. Br J Surg. 1989; 76(5):479-80. DOI: 10.1002/bjs.1800760517. View

19.

Parkinson F, Ferguson S, Lewis P, Williams I, Twine C . Rupture rates of untreated large abdominal aortic aneurysms in patients unfit for elective repair. J Vasc Surg. 2015; 61(6):1606-12. DOI: 10.1016/j.jvs.2014.10.023. View

20.

Choke E, Vijaynagar B, Thompson J, Nasim A, Bown M, Sayers R . Changing epidemiology of abdominal aortic aneurysms in England and Wales: older and more benign?. Circulation. 2012; 125(13):1617-25. DOI: 10.1161/CIRCULATIONAHA.111.077503. View