A Benzothiadiazole-Based Zn(II) Metal-Organic Framework with Visual Turn-On Sensing for Anthrax Biomarker and Theoretical Calculation

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Jun 27

PMID 38930821

Authors

Jing Ru

Yi-Xuan Shi

Qing-Yun Yang

Teng Li

Hai-Ying Wang

Fan Cao

Qiang Guo

Yan-Lan Wang

Affiliations

Soon will be listed here.

Abstract

2,6-pyridine dicarboxylic acid (DPA) is an exceptional biomarker of notorious anthrax spores. Therefore, the rapid, sensitive, and selective quantitative detection of DPA is extremely significant and urgent. This paper reports a Zn(II) metal-organic framework with the formula of {[Zn(NDA)(DPBT)] 2HO·3DMF} (MOF-1), which consists of 2,6-naphthalenedicarboxylic acid (2,6-NDA), 4,7-di(4-pyridyl)-2,1,3-benzothiadiazole (DPBT), and Zn(II) ions. Structural analysis indicated that MOF-1 is a three-dimensional (3D) network which crystallized in the monoclinic system with the 2/c space group, revealing high pH, solvent, and thermal stability. Luminescence sensing studies demonstrated that MOF-1 had the potential to be a highly selective, sensitive, and recyclable fluorescence sensor for the identification of DPA. Furthermore, fluorescent test paper was made to detect DPA promptly with color changes. The enhancement mechanism was established by the hydrogen-bonding interaction and photoinduced electron transfer transition between MOF-1 and DPA molecules.

References

Rani P, Husain A, Bhasin K, Kumar G . Zinc(II)-MOF: A Versatile Luminescent Sensor for Selective Molecular Recognition of Flame Retardants and Antibiotics. Inorg Chem. 2024; 63(7):3486-3498. DOI: 10.1021/acs.inorgchem.3c04214. View

Chaudhary M, Kanzariya D, Das A, Pal T . A fluorescent MOF and its synthesized MOF@cotton composite: Ratiometric sensing of vitamin B and antibiotic drug molecule. Spectrochim Acta A Mol Biomol Spectrosc. 2024; 314:124194. DOI: 10.1016/j.saa.2024.124194. View

Humphrey W, Dalke A, Schulten K . VMD: visual molecular dynamics. J Mol Graph. 1996; 14(1):33-8, 27-8. DOI: 10.1016/0263-7855(96)00018-5. View

Han Y, Zhou S, Wang L, Guan X . Nanopore back titration analysis of dipicolinic acid. Electrophoresis. 2014; 36(3):467-70. PMC: 4511083. DOI: 10.1002/elps.201400255. View

Mawatari K, Atsumi M, Nakamura F, Yasuda M, Fukuuchi T, Yamaoka N . Determination of Dipicolinic Acid in "Natto" by High-Performance Liquid Chromatography Coupled With Postcolumn Photoirradiation With Zinc Acetate. Int J Tryptophan Res. 2019; 12:1178646919852120. PMC: 6585242. DOI: 10.1177/1178646919852120. View

Guo X, Zhou L, Liu X, Tan G, Yuan F, Nezamzadeh-Ejhieh A . Fluorescence detection platform of metal-organic frameworks for biomarkers. Colloids Surf B Biointerfaces. 2023; 229:113455. DOI: 10.1016/j.colsurfb.2023.113455. View

Mallick A, El-Zohry A, Shekhah O, Yin J, Jia J, Aggarwal H . Unprecedented Ultralow Detection Limit of Amines using a Thiadiazole-Functionalized Zr(IV)-Based Metal-Organic Framework. J Am Chem Soc. 2019; 141(18):7245-7249. DOI: 10.1021/jacs.9b01839. View

Geng J, Li Y, Lin H, Liu Q, Lu J, Wang X . A new three-dimensional zinc(II) metal-organic framework as a fluorescence sensor for sensing the biomarker 3-nitrotyrosine. Dalton Trans. 2022; 51(30):11390-11396. DOI: 10.1039/d2dt01800d. View

Lu T, Chen F . Multiwfn: a multifunctional wavefunction analyzer. J Comput Chem. 2011; 33(5):580-92. DOI: 10.1002/jcc.22885. View

10.

Grimme S, Ehrlich S, Goerigk L . Effect of the damping function in dispersion corrected density functional theory. J Comput Chem. 2011; 32(7):1456-65. DOI: 10.1002/jcc.21759. View

11.

Sheldrick G . Crystal structure refinement with SHELXL. Acta Crystallogr C Struct Chem. 2015; 71(Pt 1):3-8. PMC: 4294323. DOI: 10.1107/S2053229614024218. View

12.

Cai D, Zheng T, Liu S, Wen H . Fluorescence sensing and device fabrication with luminescent metal-organic frameworks. Dalton Trans. 2023; 53(2):394-409. DOI: 10.1039/d3dt03223j. View

13.

Liu H, Song J, Zhao Z, Zhao S, Tian Z, Yan F . Organic Electrochemical Transistors for Biomarker Detections. Adv Sci (Weinh). 2024; 11(27):e2305347. PMC: 11251571. DOI: 10.1002/advs.202305347. View

14.

Dong J, Dao X, Zhang X, Zhang X, Sun W . Sensing Properties of NH-MIL-101 Series for Specific Amino Acids via Turn-On Fluorescence. Molecules. 2021; 26(17). PMC: 8434598. DOI: 10.3390/molecules26175336. View

15.

Hong C, Li L, Zou J, Zhang L, You S . A turn-on fluorescent Zn(II) metal-organic framework sensor for quantitative anthrax biomarker detection. Dalton Trans. 2023; 52(18):6067-6076. DOI: 10.1039/d3dt00619k. View

16.

Cong Z, Zhu M, Zhang Y, Yao W, Kosinova M, Fedin V . Three novel metal-organic frameworks with different coordination modes for trace detection of anthrax biomarkers. Dalton Trans. 2021; 51(1):250-256. DOI: 10.1039/d1dt03760a. View

17.

Pavlov D, Yu X, Ryadun A, Samsonenko D, Dorovatovskii P, Lazarenko V . Multiresponsive luminescent metal-organic framework for cooking oil adulteration detection and gallium(III) sensing. Food Chem. 2024; 445:138747. DOI: 10.1016/j.foodchem.2024.138747. View

18.

Lu T, Chen Q . Independent gradient model based on Hirshfeld partition: A new method for visual study of interactions in chemical systems. J Comput Chem. 2022; 43(8):539-555. DOI: 10.1002/jcc.26812. View

19.

Wang N, Li S, Li Z, Gong Y, Li X . A Zn(II)-Metal-Organic Framework Based on 4-(4-Carboxy phenoxy) Phthalate Acid as Luminescent Sensor for Detection of Acetone and Tetracycline. Molecules. 2023; 28(3). PMC: 9921817. DOI: 10.3390/molecules28030999. View

20.

Wang Z, Hu L, Gao Y, Kong F, Li H, Zhu J . Aggregation-Induced Emission Behavior of Dual-NIR-Emissive Zinc-Doped Carbon Nanosheets for Ratiometric Anthrax Biomarker Detection. ACS Appl Bio Mater. 2022; 3(12):9031-9042. DOI: 10.1021/acsabm.0c01260. View