In Vitro Virucidal Activity of Different Essential Oils Against Bovine Viral Diarrhea Virus Used As Surrogate of Human Hepatitis C Virus

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2024 Jun 27

PMID 38927181

Authors

Gianvito Lanave

Francesco Pellegrini

Francesco Triggiano

Osvalda De Giglio

Maria Stella Lucente

Georgia Diakoudi

Cristiana Catella

Arturo Gentile

Roberta Tardugno

Giuseppe Fracchiolla

Vito Martella

Michele Camero

Affiliations

Soon will be listed here.

Abstract

The hepatitis C virus (HCV) is a major hepatotropic virus that affects humans with increased risk of developing hepatocellular carcinoma. The bovine viral diarrhea virus (BVDV) causes abortion, calf mortality and poor reproductive performance in cattle. Due the difficulties of in vitro cultivation for HCV, BVDV has been used as surrogate for in vitro assessment of the efficacy of antivirals. Essential oils (EOs) display antiviral and virucidal activity on several viral pathogens. In this study, the virucidal activity of five EOs, L. EO (SEO), L. EO (MEO), EO (LEO), L. EO (REO) and L. EO (TEO) against BVDV was evaluated in vitro at different concentrations for several time contacts. MEO and LEO were able to considerably inactivate BVDV with a time- and dose-dependent fashion. MEO and LEO at the highest concentrations decreased viral titer by 2.00 and 2.25 log TCID/50 μL at 8 h contact time, respectively. SEO, REO and TEO displayed mild virucidal activity at the highest concentrations for 8 h contact times. In this study, the virucidal efficacies of MEO and LEO against BVDV were observed regardless of compound concentration and contact time. Further studies are needed to confirm the potential use of MEO and LEO as surface disinfectants.

Citing Articles

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PMID: 39591244 PMC: 11598475. DOI: 10.3390/toxins16110489.

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