Prevalence and Clinical Implications of Bloodstream Infections in Intensive Care Patients with or Without Burn Injury: a Retrospective Cohort Study

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 2024 Jun 26

PMID 38922377

Authors

Felix Bergmann

Anselm Jorda

Julia Sollner

Rebecca Sawodny

Kerstin Kammerer

Valerie List

Marlene Prager

Georg Gelbenegger

Katarina Kumpf

Heimo Lagler

Markus Zeitlinger

Christine Radtke

Affiliations

Soon will be listed here.

Abstract

Purpose: Severe burn injuries are often accompanied by infections and associated with high morbidity and mortality. This study aimed to compare the prevalence and clinical impact of bacteremia between patients receiving intensive care with and without burns.

Methods: This single-center retrospective cohort study at the University Hospital Vienna, Austria, analyzed blood cultures from intensive care unit (ICU) patients with and without burns (2012-2022) to assess the prevalence of bacteremia, the associated pathogen distribution and the 60-day all-cause mortality.

Results: In 1170 ICU patients, 303 with burns and 867 without, the prevalence of bacteremia was similar among patients with at least one blood culture (31/157 [19.7%] versus 44/213 [20.7%], OR [95%CI] = 0.95 [0.57-1.57]). Burn patients exhibited a significantly higher frequency of microbiological sampling (51.5% versus 24.5%, p < 0.001), resulting in a higher overall prevalence of bacteremia (10.2% versus 5.1%, p = 0.002). 16.2% of all identified pathogens were multidrug-resistant (MDR). The 60-day all-cause mortality was higher in patients with MDR pathogens than in patients without bacteremia (41.7% versus 10.6%, p = 0.026).

Conclusion: Bacteremia prevalence was similar in burn and non-burn patients, with high rates of multidrug-resistant Gram-negative pathogens. The 60-day all-cause mortality was significantly higher in patients with MDR pathogens than in patients without bacteremia.

Citing Articles

Enrichment of H3S28p and H3K9me2 Epigenetic Marks on Inflammatory-Associated Gene Promoters in Response to Severe Burn Injury.

Arias-Perez O, Escobedo-Tapia T, Cintora-Ahumada C, Leon-Solis L, Leyva-Garcia N, Arechaga-Ocampo E Life (Basel). 2025; 14(12.

PMID: 39768289 PMC: 11677237. DOI: 10.3390/life14121581.

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