Secondary Metabolites from Marine-Derived Fungus BTBU20213035

Overview

Journal J Fungi (Basel)

Date 2024 Jun 26

PMID 38921410

Authors

Xiuli Xu

Yifei Dong

Jinpeng Yang

Long Wang

Linlin Ma

Fuhang Song

Xiaoli Ma

Affiliations

Soon will be listed here.

Abstract

Two new polyketide derivatives, penirubenones A and B ( and ), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B ( and ), together with nine known compounds (-) were isolated from the marine-derived fungus BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and C NMR data. We found that exhibited antibacterial activity against , with an MIC value of 3.125 μg/mL, and and showed synergistic antifungal activity against at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.

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