Marine-Derived Penicillium Species As Producers of Cytotoxic Metabolites

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2017 Oct 25

PMID 29064452

Citations 28

Authors

Sen Liu

Mingzhi Su

Shao-Jiang Song

Jee H Jung

Affiliations

Soon will be listed here.

Abstract

Since the discovery of penicillin, has become one of the most attractive fungal genera for the production of bioactive molecules. Marine-derived has provided numerous excellent pharmaceutical leads over the past decades. In this review, we focused on the cytotoxic metabolites * (* Cytotoxic potency was referred to five different levels in this review, extraordinary (IC/LD: <1 μM or 0.5 μg/mL); significant (IC/LD: 1~10 μM or 0.5~5 μg/mL); moderate (IC/LD: 10~30 μM or 5~15 μg/mL); mild (IC/LD: 30~50 μM or 15~25 μg/mL); weak (IC/LD: 50~100 μM or 25~50 μg/mL). The comparative potencies of positive controls were referred when they were available). produced by marine-derived species, and on their cytotoxicity mechanisms, biosyntheses, and chemical syntheses.

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