Synthesis of Chitosan and Ferric-Ion (Fe)-Doped Brushite Mineral Cancellous Bone Scaffolds

Overview

Journal Biomimetics (Basel)

Date 2024 Jun 26

PMID 38921188

Authors

Lemiha Yildizbakan

Neelam Iqbal

Peter V Giannoudis

Animesh Jha

Affiliations

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Abstract

Biodegradable scaffolds are needed to repair bone defects. To promote the resorption of scaffolds, a large surface area is required to encourage neo-osteogenesis. Herein, we describe the synthesis and freeze-drying methodologies of ferric-ion (Fe) doped Dicalcium Phosphate Dihydrate mineral (DCPD), also known as brushite, which has been known to favour the in situ condition for osteogenesis. In this investigation, the role of chitosan during the synthesis of DCPD was explored to enhance the antimicrobial, scaffold pore distribution, and mechanical properties post freeze-drying. During the synthesis of DCPD, the calcium nitrate solution was hydrolysed with a predetermined stoichiometric concentration of ammonium phosphate. During the hydrolysis reaction, 10 (mol)% iron (Fe) nitrate (Fe(NO)) was incorporated, and the DCPD minerals were precipitated (Fe-DCPD). Chitosan stir-mixed with Fe-DCPD minerals was freeze-dried to create scaffolds. The structural, microstructural, and mechanical properties of freeze-dried materials were characterized.

Citing Articles

Chitosan Scaffolds from Crustacean and Fungal Sources: A Comparative Study for Bone-Tissue-Engineering Applications.

Iqbal N, Ganguly P, Yildizbakan L, Raif E, Jones E, Giannoudis P Bioengineering (Basel). 2024; 11(7).

PMID: 39061802 PMC: 11273506. DOI: 10.3390/bioengineering11070720.

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