Chitosan-based Scaffolds for Bone Tissue Engineering

Overview

Journal J Mater Chem B

Publisher Royal Society of Chemistry

Specialty Biomedical Engineering

Date 2014 Jul 8

PMID 24999429

Citations 133

Authors

Sheeny Lan Levengood

Miqin Zhang

Affiliations

Soon will be listed here.

Abstract

Bone defects requiring grafts to promote healing are frequently occurring and costly problems in health care. Chitosan, a biodegradable, naturally occurring polymer, has drawn considerable attention in recent years as scaffolding material in tissue engineering and regenerative medicine. Chitosan is especially attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblast cells as well as formation of mineralized bone matrix. In this review, we discuss the fundamentals of bone tissue engineering and the unique properties of chitosan as a scaffolding material to treat bone defects for hard tissue regeneration. We present the common methods for fabrication and characterization of chitosan scaffolds, and discuss the influence of material preparation and addition of polymeric or ceramic components or biomolecules on chitosan scaffold properties such as mechanical strength, structural integrity, and functional bone regeneration. Finally, we highlight recent advances in development of chitosan-based scaffolds with enhanced bone regeneration capability.

Citing Articles

Influence of Electron Beam Irradiation and RPMI Immersion on the Development of Magnesium-Doped Hydroxyapatite/Chitosan Composite Bioactive Layers for Biomedical Applications.

Groza A, Hurjui M, Yehia-Alexe S, Staicu C, Bleotu C, Iconaru S Polymers (Basel). 2025; 17(4).

PMID: 40006195 PMC: 11858993. DOI: 10.3390/polym17040533.

Fabrication and cytocompatibility evaluation of porous bone scaffold based on cuttlefish bone-derived nano-carbonated hydroxyapatite reinforced with polyethylene oxide/chitosan fibrous structure.

Habiburrohman M, Jamilludin M, Cahyati N, Herdianto N, Yusuf Y RSC Adv. 2025; 15(7):5135-5150.

PMID: 39963456 PMC: 11831101. DOI: 10.1039/d4ra08457h.

3D Porous Polycaprolactone with Chitosan-Graft-PCL Modified Surface for In Situ Tissue Engineering.

Pitts J, Hansch R, Roger Y, Hoffmann A, Menzel H Polymers (Basel). 2025; 17(3).

PMID: 39940585 PMC: 11820431. DOI: 10.3390/polym17030383.

Histology Assessment of Chitosan-Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles.

Grande-Tovar C, Castro Castro J, Barba-Rosado L, Zapata P, Insuasty D, Valencia-Llano C Molecules. 2025; 30(2).

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GelMA hydrogels reinforced by PCL@GelMA nanofibers and bioactive glass induce bone regeneration in critical size cranial defects.

Yu C, Chen J, Wang T, Wang Y, Zhang X, Zhang Z J Nanobiotechnology. 2024; 22(1):696.

PMID: 39529025 PMC: 11552337. DOI: 10.1186/s12951-024-02980-w.

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