Early Poststroke Clinically Significant Fatigue Predicts Functional Independence: a Prospective Longitudinal Study

Overview

Journal Front Neurol

Specialty Neurology

Date 2024 Jun 26

PMID 38919969

Authors

Alan Juarez-Belaunde

Vanesa Soto-Leon

Michele Dileone

Elena Orcajo

Natacha Leon-Alvarez

Alberto Munoz

Jesus Tornero

Antonio Oliviero

Affiliations

Soon will be listed here.

Abstract

Background: Poststroke fatigue is a prevalent issue among stroke survivors, significantly impeding functional recovery and diminishing their quality of life.

Aim: This prospective cohort study aims to investigate the association between poststroke fatigue and the extent of functional recovery in survivors of ischemic and hemorrhagic strokes. Additionally, it seeks to delineate the temporal progression of poststroke fatigue in these two stroke subtypes.

Methods: We assessed a cohort of 79 patients recovering from acute ischemic or hemorrhagic strokes. Poststroke fatigue was quantified using the Fatigue Severity Scale (FSS) and the Numeric Rating Scale (NRS). Patients' condition was evaluated using the National Institute of Health Stroke Scale (NIHSS), and functional independence levels were determined using the Barthel Index for Activities of Daily Living (BIADL) and the Modified Rankin Scale (MRS). Depressive mood and pain were measured using the Beck Depression Inventory (BDI) and the Numeric Rating Scale for pain (NRSpain), respectively.

Results: Our primary findings indicate that the early manifestation of clinically significant fatigue (CSF) is predictive of a poorer trajectory in functional independence levels during recovery. Furthermore, we observed differing patterns of fatigue progression between ischemic and hemorrhagic strokes. Fatigue tends to ameliorate over time in hemorrhagic stroke cases, paralleling functional recovery, while it remains stable over time in ischemic stroke cases.

Conclusion: Our results underscore the detrimental impact of early poststroke fatigue on long-term outcomes. Furthermore, they highlight the imperative of managing poststroke fatigue, particularly during the subacute phase of stroke recovery.

Citing Articles

Dysphagia increases the risk of post-stroke fatigue.

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Post-stroke fatigue and its correlation with family functioning in patients who have experienced a first episode of stroke.

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