A Roadmap for Research in Post-stroke Fatigue: Consensus-based Core Recommendations from the Third Stroke Recovery and Rehabilitation Roundtable

Overview

Journal Neurorehabil Neural Repair

Publisher Sage Publications

Specialties Neurology
Rehabilitation Medicine

Date 2023 Oct 14

PMID 37837346

Authors

Coralie English

Dawn B Simpson

Sandra A Billinger

Leonid Churilov

Kirsten G Coupland

Avril Drummond

Annapoorna Kuppuswamy

Mansur A Kutlubaev

Anners Lerdal

Amreen Mahmood

G Lorimer Moseley

Quentin J Pittman

Ellyn A Riley

Brad A Sutherland

Connie Hy Wong

Dale Corbett

Gillian Mead

Affiliations

Soon will be listed here.

Abstract

Rationale: Fatigue affects almost half of all people living with stroke. Stroke survivors rank understanding fatigue and how to reduce it as one of the highest research priorities.

Methods: We convened an interdisciplinary, international group of clinical and pre-clinical researchers and lived experience experts. We identified four priority areas: (1) best measurement tools for research, (2) clinical identification of fatigue and potentially modifiable causes, (3) promising interventions and recommendations for future trials, and (4) possible biological mechanisms of fatigue. Cross-cutting themes were aphasia and the voice of people with lived experience. Working parties were formed and structured consensus building processes were followed.

Results: We present 20 recommendations covering outcome measures for research, development, and testing of new interventions and priority areas for future research on the biology of post-stroke fatigue. We developed and recommend the use of the Stroke Fatigue Clinical Assessment Tool.

Conclusions: By synthesizing current knowledge in post-stroke fatigue across clinical and pre-clinical fields, our work provides a roadmap for future research into post-stroke fatigue.

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