Evaluating the Role of Probiotics, Prebiotics, and Synbiotics Supplementation in Age-related Musculoskeletal Disorders in Older Adults: A Systematic Review

Overview

Journal Probiotics Antimicrob Proteins

Publisher Springer

Specialties Infectious Diseases
Microbiology
Nutritional Sciences
Pharmacology

Date 2024 Jun 22

PMID 38907826

Authors

Narges Lashkarbolouk

Mahdi Mazandarani

Azin Pakmehr

Hanieh-Sadat Ejtahed

Affiliations

Soon will be listed here.

Abstract

The aim of this systematic review is to evaluate musculoskeletal changes in response to prebiotics, probiotics, or synbiotics supplementation in older adults or in animal models of aging musculoskeletal disorders. A comprehensive search was conducted on electronic databases, including PubMed/Medline, Cochrane, and Web of Science until April 2024. The quality assessment of clinical trials was conducted using the Cochrane Collaboration tool and for animal studies, the SYRCLE's tool was used. Our literature search resulted in 652 studies. After removing duplicates and screening the articles based on their titles and abstracts, we assessed the full text of 112 articles, which yielded 20 clinical trials and 30 animal studies in our systematic review. Most of human and animal studies reported an improvement in physical performance, a decrease in frailty index, and a lower reduction in bone mineral density in the intervention groups. Body composition tends to increase in muscle ratio, muscle mass, and reduce in appendicular lean mass and muscle atrophy. Also, the intervention induced bone turnover and mineral absorption, significantly increasing Ca, P, and Mg absorption and short-chain fatty acid concentration. Additionally, levels of inflammatory markers such as IL1, IL6, IL17, T helper 17, and TNF-α exhibited a decreasing trend, while an increase in IL10 and IFN-γ was observed. Prebiotics, probiotics, or synbiotics supplementations could effectively improve the physical performance and muscle strength and reduce the risk of bone loss and frailty in the elderly.

References

Wilms E, An R, Smolinska A, Stevens Y, Weseler A, Elizalde M . Galacto-oligosaccharides supplementation in prefrail older and healthy adults increased faecal bifidobacteria, but did not impact immune function and oxidative stress. Clin Nutr. 2021; 40(5):3019-3031. DOI: 10.1016/j.clnu.2020.12.034. View

Lei M, Guo C, Wang D, Zhang C, Hua L . The effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: a randomised double-blind, placebo-controlled clinical trial. Benef Microbes. 2017; 8(5):697-703. DOI: 10.3920/BM2016.0207. View

Ford A, Nagulesapillai V, Piano A, Auger J, Girard S, Christman M . Microbiota Stability and Gastrointestinal Tolerance in Response to a High-Protein Diet with and without a Prebiotic, Probiotic, and Synbiotic: A Randomized, Double-Blind, Placebo-Controlled Trial in Older Women. J Acad Nutr Diet. 2020; 120(4):500-516.e10. DOI: 10.1016/j.jand.2019.12.009. View

Theou O, Jayanama K, Fernandez-Garrido J, Buigues C, Pruimboom L, Hoogland A . Can a Prebiotic Formulation Reduce Frailty Levels in Older People?. J Frailty Aging. 2019; 8(1):48-52. DOI: 10.14283/jfa.2018.39. View

Tominaga K, Tsuchiya A, Nakano O, Kuroki Y, Oka K, Minemura A . Increase in muscle mass associated with the prebiotic effects of 1-kestose in super-elderly patients with sarcopenia. Biosci Microbiota Food Health. 2021; 40(3):150-155. PMC: 8279888. DOI: 10.12938/bmfh.2020-063. View

Jafarnejad S, Djafarian K, Fazeli M, Yekaninejad M, Rostamian A, Keshavarz S . Effects of a Multispecies Probiotic Supplement on Bone Health in Osteopenic Postmenopausal Women: A Randomized, Double-blind, Controlled Trial. J Am Coll Nutr. 2017; 36(7):497-506. DOI: 10.1080/07315724.2017.1318724. View

Lambert M, Thybo C, Lykkeboe S, Rasmussen L, Frette X, Christensen L . Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr. 2017; 106(3):909-920. DOI: 10.3945/ajcn.117.153353. View

Lei M, Hua L, Wang D . The effect of probiotic treatment on elderly patients with distal radius fracture: a prospective double-blind, placebo-controlled randomised clinical trial. Benef Microbes. 2016; 7(5):631-637. DOI: 10.3920/BM2016.0067. View

Liu C, Cheung W, Li J, Chow S, Yu J, Wong S . Understanding the gut microbiota and sarcopenia: a systematic review. J Cachexia Sarcopenia Muscle. 2021; 12(6):1393-1407. PMC: 8718038. DOI: 10.1002/jcsm.12784. View

10.

Coutts L, Ibrahim K, Tan Q, Lim S, Cox N, Roberts H . Can probiotics, prebiotics and synbiotics improve functional outcomes for older people: a systematic review. Eur Geriatr Med. 2020; 11(6):975-993. PMC: 7515554. DOI: 10.1007/s41999-020-00396-x. View

11.

Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland A, Navarro-Martinez R, Martinez-Martinez M . Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial. Int J Mol Sci. 2016; 17(6). PMC: 4926465. DOI: 10.3390/ijms17060932. View

12.

Nilsson A, Sundh D, Backhed F, Lorentzon M . Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial. J Intern Med. 2018; 284(3):307-317. DOI: 10.1111/joim.12805. View

13.

Li P, Sundh D, Ji B, Lappa D, Ye L, Nielsen J . Metabolic Alterations in Older Women With Low Bone Mineral Density Supplemented With . JBMR Plus. 2021; 5(4):e10478. PMC: 8046097. DOI: 10.1002/jbm4.10478. View

14.

Lee M, Tu Y, Lee C, Tsai S, Hsu H, Tsai T . TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial. Microorganisms. 2021; 9(7). PMC: 8305125. DOI: 10.3390/microorganisms9071466. View

15.

Rondanelli M, Gasparri C, Barrile G, Battaglia S, Cavioni A, Giusti R . Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic PS23 for the Treatment of Sarcopenia in Elderly Subjects: A 2-Month Randomized Double-Blind Placebo-Controlled Trial. Nutrients. 2022; 14(21). PMC: 9656258. DOI: 10.3390/nu14214566. View

16.

Calero C, Rincon E, Marqueta P . Probiotics, prebiotics and synbiotics: useful for athletes and active individuals? A systematic review. Benef Microbes. 2020; 11(2):135-149. DOI: 10.3920/BM2019.0076. View

17.

Byeon H, Jang S, Lee Y, Kim D, Hong M, Lee D . New Strains of and are Effective for Improving the Muscle Strength of Mice with Immobilization-Induced Muscular Atrophy. J Med Food. 2022; 25(6):565-575. DOI: 10.1089/jmf.2021.K.0148. View

18.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. PMC: 2707010. DOI: 10.1371/journal.pmed.1000100. View

19.

Jansson P, Curiac D, Lazou Ahren I, Hansson F, Martinsson Niskanen T, Sjogren K . Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet Rheumatol. 2024; 1(3):e154-e162. DOI: 10.1016/S2665-9913(19)30068-2. View

20.

McGrail L, Vargas-Robles D, Correa M, Merrill L, Noel S, Velez M . Daily yogurt consumption does not affect bone turnover markers in men and postmenopausal women of Caribbean Latino descent: a randomized controlled trial. BMC Nutr. 2024; 10(1):12. PMC: 10785535. DOI: 10.1186/s40795-023-00800-2. View