Sugar-sweetened Beverage but Not Diluted Cloudy Apple Juice Consumption Induces Post-prandial Endotoxemia in Healthy Adults

Overview

Journal NPJ Sci Food

Publisher Springer Nature

Date 2024 Jun 21

PMID 38906893

Authors

Raphaela Staltner

Sarah Valder

Maximilian F Wodak

Magdalena Kopsel

Volker Herdegen

Tuba Esatbeyoglu

Tihomir Kostov

Patrick Diel

Ina Bergheim

Affiliations

Soon will be listed here.

Abstract

Sugar beverages are discussed as critical in the development of metabolic endotoxemia. Here, employing a cross-over design study we assessed the effect of diluted cloudy apple juice (AJ), an iso-caloric and -sweetened placebo (P), or water (W) on post-prandial endotoxemia in healthy, normal weight adults. After obtaining fasting blood, 19 healthy men and women consumed 500 mL AJ, P, or W in a randomized order and blood was taken 120 and 180 min later. Caco-2 cells were incubated with the beverages. Markers of intestinal barrier function were assessed. The intake of P but not of AJ or W was associated with a significant increase in TLR2 ligands and bacterial endotoxin in serum after 120 min and 180 min, respectively. P but not AJ significantly increased bacterial toxin permeation in Caco-2 cells. Our results suggest that the effects of sugar-sweetened beverages on markers of intestinal barrier function markedly differ from those of fruit juices.

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