» Articles » PMID: 38896539

A Qualitative Assessment of Using ChatGPT As Large Language Model for Scientific Workflow Development

Overview
Journal Gigascience
Specialties Biology
Genetics
Date 2024 Jun 19
PMID 38896539
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Scientific workflow systems are increasingly popular for expressing and executing complex data analysis pipelines over large datasets, as they offer reproducibility, dependability, and scalability of analyses by automatic parallelization on large compute clusters. However, implementing workflows is difficult due to the involvement of many black-box tools and the deep infrastructure stack necessary for their execution. Simultaneously, user-supporting tools are rare, and the number of available examples is much lower than in classical programming languages.

Results: To address these challenges, we investigate the efficiency of large language models (LLMs), specifically ChatGPT, to support users when dealing with scientific workflows. We performed 3 user studies in 2 scientific domains to evaluate ChatGPT for comprehending, adapting, and extending workflows. Our results indicate that LLMs efficiently interpret workflows but achieve lower performance for exchanging components or purposeful workflow extensions. We characterize their limitations in these challenging scenarios and suggest future research directions.

Conclusions: Our results show a high accuracy for comprehending and explaining scientific workflows while achieving a reduced performance for modifying and extending workflow descriptions. These findings clearly illustrate the need for further research in this area.

Citing Articles

A qualitative assessment of using ChatGPT as large language model for scientific workflow development.

Sanger M, De Mecquenem N, Lewinska K, Bountris V, Lehmann F, Leser U Gigascience. 2024; 13.

PMID: 38896539 PMC: 11186067. DOI: 10.1093/gigascience/giae030.

References
1.
Ison J, Ienasescu H, Chmura P, Rydza E, Menager H, Kalas M . The bio.tools registry of software tools and data resources for the life sciences. Genome Biol. 2019; 20(1):164. PMC: 6691543. DOI: 10.1186/s13059-019-1772-6. View

2.
Wratten L, Wilm A, Goke J . Reproducible, scalable, and shareable analysis pipelines with bioinformatics workflow managers. Nat Methods. 2021; 18(10):1161-1168. DOI: 10.1038/s41592-021-01254-9. View

3.
Kim D, Paggi J, Park C, Bennett C, Salzberg S . Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol. 2019; 37(8):907-915. PMC: 7605509. DOI: 10.1038/s41587-019-0201-4. View

4.
Chen S, Zhou Y, Chen Y, Gu J . fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 2018; 34(17):i884-i890. PMC: 6129281. DOI: 10.1093/bioinformatics/bty560. View

5.
Goecks J, Nekrutenko A, Taylor J . Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Genome Biol. 2010; 11(8):R86. PMC: 2945788. DOI: 10.1186/gb-2010-11-8-r86. View