» Articles » PMID: 38890909

Dietary Strategies to Improve Exercise Performance by Modulating the Gut Microbiota

Overview
Journal Foods
Specialty Biotechnology
Date 2024 Jun 19
PMID 38890909
Authors
Affiliations
Soon will be listed here.
Abstract

Numerous research studies have shown that moderate physical exercise exerts positive effects on gastrointestinal tract health and increases the variety and relative number of beneficial microorganisms in the intestinal microbiota. Increasingly, studies have shown that the gut microbiota is critical for energy metabolism, immunological response, oxidative stress, skeletal muscle metabolism, and the regulation of the neuroendocrine system, which are significant for the physiological function of exercise. Dietary modulation targeting the gut microbiota is an effective prescription for improving exercise performance and alleviating exercise fatigue. This article discusses the connection between exercise and the makeup of the gut microbiota, as well as the detrimental effects of excessive exercise on gut health. Herein, we elaborate on the possible mechanism of the gut microbiota in improving exercise performance, which involves enhancing skeletal muscle function, reducing oxidative stress, and regulating the neuroendocrine system. The effects of dietary nutrition strategies and probiotic supplementation on exercise from the perspective of the gut microbiota are also discussed in this paper. A deeper understanding of the potential mechanism by which the gut microbiota exerts positive effects on exercise and dietary nutrition recommendations targeting the gut microbiota is significant for improving exercise performance. However, further investigation is required to fully comprehend the intricate mechanisms at work.

Citing Articles

Study on the Effect of Bifidobacterium adolescentis CCFM1066 on Exercise Performance, Gut Microbiota, and Its Metabolites in Mice.

Wang H, Ma H, Yan H, Pei Z, Zhao J, Zhang H Probiotics Antimicrob Proteins. 2025; .

PMID: 40064789 DOI: 10.1007/s12602-025-10493-7.


Gut microbiota and atrial cardiomyopathy.

Sun T, Song B, Li B Front Cardiovasc Med. 2025; 12:1541278.

PMID: 39968343 PMC: 11832500. DOI: 10.3389/fcvm.2025.1541278.


Effects of Kefir Consumption on Gut Microbiota and Athletic Performance in Professional Female Soccer Players: A Randomized Controlled Trial.

Ones E, Zavotcu M, Nisan N, Bas M, Saglam D Nutrients. 2025; 17(3).

PMID: 39940370 PMC: 11820909. DOI: 10.3390/nu17030512.


Mechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes.

Nami Y, Barghi A, Shahgolzari M, Salehian M, Haghshenas B Food Sci Nutr. 2025; 13(1):e4658.

PMID: 39803224 PMC: 11717059. DOI: 10.1002/fsn3.4658.


Intestinal Microbiota Interventions to Enhance Athletic Performance-A Review.

Patel B, Patel K, Lee C, Moochhala S Int J Mol Sci. 2024; 25(18).

PMID: 39337561 PMC: 11432184. DOI: 10.3390/ijms251810076.

References
1.
Cai J, Chen Z, Wu W, Lin Q, Liang Y . High animal protein diet and gut microbiota in human health. Crit Rev Food Sci Nutr. 2021; 62(22):6225-6237. DOI: 10.1080/10408398.2021.1898336. View

2.
Kaji I, Karaki S, Kuwahara A . Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release. Digestion. 2014; 89(1):31-6. DOI: 10.1159/000356211. View

3.
Frampton J, Murphy K, Frost G, Chambers E . Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function. Nat Metab. 2020; 2(9):840-848. DOI: 10.1038/s42255-020-0188-7. View

4.
Wu L, Zhou M, Li T, Dong N, Yi L, Zhang Q . GLP-1 regulates exercise endurance and skeletal muscle remodeling via GLP-1R/AMPK pathway. Biochim Biophys Acta Mol Cell Res. 2022; 1869(9):119300. DOI: 10.1016/j.bbamcr.2022.119300. View

5.
Morkl S, Butler M, Holl A, Cryan J, Dinan T . Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry. Curr Nutr Rep. 2020; 9(3):171-182. PMC: 7398953. DOI: 10.1007/s13668-020-00313-5. View