The Effects of and Combination on Diet-Induced Obesity and Gut Microbiota

Overview

Journal Foods

Specialty Biotechnology

Date 2024 Jun 19

PMID 38890862

Authors

Jingjing Yuan

Yueyun Hu

Dongmei Yang

An Zhou

ShengYong Luo

Na Xu

Jiaxing Dong

Qing He

Chenxu Zhang

Xinyu Zhang

Zhangxin Ji

Qinglin Li

Jun Chu

Affiliations

Soon will be listed here.

Abstract

Obesity is a multifactorial chronic metabolic disease with multiple complications. (CP) and (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

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