Retrospective Characterization of Bone Histomorphometric Findings in Clinical Patient Specimens

Overview

Journal J Bone Metab

Date 2024 Jun 18

PMID 38886970

Authors

Linnea Sellman

Xiaoyu Tong

Inari S Burton

Heikki Kroger

Affiliations

Soon will be listed here.

Abstract

Background: Bone histomorphometry provides comprehensive information on bone metabolism and microstructure. In this retrospective study, we aimed to obtain an overview of the typical indications, referring hospitals, and histomorphometric quantification-based diagnoses of the bone tissue in our histomorphometry laboratory, the only laboratory in Finland carrying out histomorphometric examination of clinical bone biopsies.

Methods: Between January 1, 2005 and December 31, 2020, 553 clinical bone biopsies were sent to our histomorphometry laboratory for histomorphometric examination. The median age of the patients was 55 years (range, 0.2-89.9 years), 51% of them were males, and 18% comprised pediatric patients. We received bone biopsy specimens from 23 hospitals or healthcare units. The majority of the samples we sent by nephrologists.

Results: The most common bone biopsy indications were suspicion of renal osteodystrophy (ROD), unknown bone turnover status in osteoporosis, and several or untypical fractures. The most common quantitative bone histomorphometry-based diagnosis was ROD.

Conclusions: This study provides information on the clinical application of bone histomorphometry in Finland. Precise and quantitative ROD evaluation is the most common indication for bone histomorphometry, being crucial in clinical decision-making and targeted treatment of this patient group.

References

Tamminen I, Mayranpaa M, Turunen M, Isaksson H, Makitie O, Jurvelin J . Altered bone composition in children with vertebral fracture. J Bone Miner Res. 2011; 26(9):2226-34. DOI: 10.1002/jbmr.409. View

Recker R, Lappe J, Davies M, Kimmel D . Perimenopausal bone histomorphometry before and after menopause. Bone. 2017; 108:55-61. DOI: 10.1016/j.bone.2017.12.016. View

Geusens P, Chapurlat R, Schett G, Ghasem-Zadeh A, Seeman E, de Jong J . High-resolution in vivo imaging of bone and joints: a window to microarchitecture. Nat Rev Rheumatol. 2014; 10(5):304-13. DOI: 10.1038/nrrheum.2014.23. View

Keronen S, Martola L, Finne P, Burton I, Kroger H, Honkanen E . Changes in Bone Histomorphometry after Kidney Transplantation. Clin J Am Soc Nephrol. 2019; 14(6):894-903. PMC: 6556726. DOI: 10.2215/CJN.09950818. View

Recker R, Kimmel D, Dempster D, Weinstein R, Wronski T, Burr D . Issues in modern bone histomorphometry. Bone. 2011; 49(5):955-64. PMC: 3274956. DOI: 10.1016/j.bone.2011.07.017. View

Pocock N . Use of dual energy X-ray absorptiometry, the trabecular bone score and quantitative computed tomography in the evaluation of chronic kidney disease-mineral and bone disorders. Nephrology (Carlton). 2017; 22 Suppl 2:19-21. DOI: 10.1111/nep.13016. View

Pietschmann P, Rauner M, Sipos W, Kerschan-Schindl K . Osteoporosis: an age-related and gender-specific disease--a mini-review. Gerontology. 2008; 55(1):3-12. DOI: 10.1159/000166209. View

Chavassieux P, Chapurlat R . Interest of Bone Histomorphometry in Bone Pathophysiology Investigation: Foundation, Present, and Future. Front Endocrinol (Lausanne). 2022; 13:907914. PMC: 9368205. DOI: 10.3389/fendo.2022.907914. View

Dalle Carbonare L, Valenti M, Giannini S, Gallieni M, Stefani F, Ciresa R . Bone Biopsy for Histomorphometry in Chronic Kidney Disease (CKD): State-of-the-Art and New Perspectives. J Clin Med. 2021; 10(19). PMC: 8509646. DOI: 10.3390/jcm10194617. View

10.

Moe S, Drueke T, Cunningham J, Goodman W, Martin K, Olgaard K . Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006; 69(11):1945-53. DOI: 10.1038/sj.ki.5000414. View

11.

Dempster D, Compston J, Drezner M, Glorieux F, Kanis J, Malluche H . Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res. 2012; 28(1):2-17. PMC: 3672237. DOI: 10.1002/jbmr.1805. View

12.

Dalle Carbonare L, Valenti M, Bertoldo F, Zanatta M, Zenari S, Realdi G . Bone microarchitecture evaluated by histomorphometry. Micron. 2005; 36(7-8):609-16. DOI: 10.1016/j.micron.2005.07.007. View

13.

Malluche H, Monier-Faugere M . Renal osteodystrophy: what's in a name? Presentation of a clinically useful new model to interpret bone histologic findings. Clin Nephrol. 2006; 65(4):235-42. DOI: 10.5414/cnp65235. View

14.

Glorieux F, Travers R, Taylor A, Bowen J, Rauch F, Norman M . Normative data for iliac bone histomorphometry in growing children. Bone. 2000; 26(2):103-9. DOI: 10.1016/s8756-3282(99)00257-4. View

15.

Jorgensen H, Ferreira A, DHaese P, Haarhaus M, Vervloet M, Lafage-Proust M . Bone histomorphometry for the diagnosis of renal osteodystrophy: a call for harmonization of reference ranges. Kidney Int. 2022; 102(2):431-434. DOI: 10.1016/j.kint.2022.04.030. View

16.

Malluche H, Davenport D, Cantor T, Monier-Faugere M . Bone mineral density and serum biochemical predictors of bone loss in patients with CKD on dialysis. Clin J Am Soc Nephrol. 2014; 9(7):1254-62. PMC: 4078960. DOI: 10.2215/CJN.09470913. View

17.

Rehman M, Hoyland J, Denton J, Freemont A . Age related histomorphometric changes in bone in normal British men and women. J Clin Pathol. 1994; 47(6):529-34. PMC: 494743. DOI: 10.1136/jcp.47.6.529. View

18.

Raum K . Microelastic imaging of bone. IEEE Trans Ultrason Ferroelectr Freq Control. 2008; 55(7):1417-31. DOI: 10.1109/TUFFC.2008.817. View

19.

Recker R, Akhter M, Lappe J, Watson P . Bone histomorphometry in transiliac biopsies from 48 normal, healthy men. Bone. 2018; 111:109-115. DOI: 10.1016/j.bone.2018.03.019. View

20.

Martin K, Gonzalez E . Metabolic bone disease in chronic kidney disease. J Am Soc Nephrol. 2007; 18(3):875-85. DOI: 10.1681/ASN.2006070771. View