Understanding Epileptogenesis from Molecules to Network Alteration

Overview

Journal Encephalitis

Date 2024 Jun 17

PMID 38886161

Authors

Kyung-Il Park

Affiliations

Soon will be listed here.

Abstract

Epilepsy is characterized by recurrent seizures. Following an initial insult, a latent period precedes the onset of spontaneous seizures, a process referred to as epileptogenesis. This period plays a critical role in halting the progression toward epilepsy before the onset of abnormal molecular and network alterations. In this study, the fundamental concepts of epileptogenesis as well as the associated molecular and cellular targets are reviewed.

References

Devinsky O, Vezzani A, Najjar S, de Lanerolle N, Rogawski M . Glia and epilepsy: excitability and inflammation. Trends Neurosci. 2013; 36(3):174-84. DOI: 10.1016/j.tins.2012.11.008. View

Simonato M, Agoston D, Brooks-Kayal A, Dulla C, Fureman B, Henshall D . Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap. Nat Rev Neurol. 2021; 17(4):231-242. DOI: 10.1038/s41582-021-00461-4. View

Johnson E, Krauss G, Lee A, Schneider A, Dearborn J, Kucharska-Newton A . Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study. JAMA Neurol. 2018; 75(11):1375-1382. PMC: 6248112. DOI: 10.1001/jamaneurol.2018.1935. View

Vezzani A, Pascente R, Ravizza T . Biomarkers of Epileptogenesis: The Focus on Glia and Cognitive Dysfunctions. Neurochem Res. 2017; 42(7):2089-2098. DOI: 10.1007/s11064-017-2271-3. View

Pitkanen A, Engel Jr J . Past and present definitions of epileptogenesis and its biomarkers. Neurotherapeutics. 2014; 11(2):231-41. PMC: 3996117. DOI: 10.1007/s13311-014-0257-2. View

Schevon C, Cappell J, Emerson R, Isler J, Grieve P, Goodman R . Cortical abnormalities in epilepsy revealed by local EEG synchrony. Neuroimage. 2007; 35(1):140-8. PMC: 1994936. DOI: 10.1016/j.neuroimage.2006.11.009. View

Park K, Chu K, Jung K, Kim J, Kang K, Lee S . Role of cortical dysplasia in epileptogenesis following prolonged febrile seizure. Epilepsia. 2010; 51(9):1809-19. DOI: 10.1111/j.1528-1167.2010.02676.x. View

Hines K, Wu C . Epilepsy Networks and Their Surgical Relevance. Brain Sci. 2024; 14(1). PMC: 10813558. DOI: 10.3390/brainsci14010031. View

Gourmaud S, Shou H, Irwin D, Sansalone K, Jacobs L, Lucas T . Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain. 2019; 143(1):191-209. PMC: 6935754. DOI: 10.1093/brain/awz381. View

10.

Smith K, Blessing M, Parisi J, Britton J, Mandrekar J, Cascino G . Tau deposition in young adults with drug-resistant focal epilepsy. Epilepsia. 2019; 60(12):2398-2403. PMC: 6973032. DOI: 10.1111/epi.16375. View

11.

Proix T, Truccolo W, Leguia M, Tcheng T, King-Stephens D, Rao V . Forecasting seizure risk in adults with focal epilepsy: a development and validation study. Lancet Neurol. 2020; 20(2):127-135. PMC: 7968722. DOI: 10.1016/S1474-4422(20)30396-3. View

12.

Jung K, Chu K, Lee S, Park K, Kim J, Kang K . Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin. Epilepsia. 2011; 52(3):541-50. DOI: 10.1111/j.1528-1167.2010.02916.x. View

13.

Vasilieva A, Timechko E, Lysova K, Paramonova A, Yakimov A, Kantimirova E . MicroRNAs as Potential Biomarkers of Post-Traumatic Epileptogenesis: A Systematic Review. Int J Mol Sci. 2023; 24(20). PMC: 10607802. DOI: 10.3390/ijms242015366. View

14.

Lillis K, Wang Z, Mail M, Zhao G, Berdichevsky Y, Bacskai B . Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. J Neurosci. 2015; 35(27):9920-34. PMC: 4495242. DOI: 10.1523/JNEUROSCI.4007-14.2015. View

15.

Immonen R, Harris N, Wright D, Johnston L, Manninen E, Smith G . Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers. Neurobiol Dis. 2018; 123:75-85. PMC: 6818714. DOI: 10.1016/j.nbd.2018.10.008. View

16.

Zeng L, Rensing N, Wong M . The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci. 2009; 29(21):6964-72. PMC: 2727061. DOI: 10.1523/JNEUROSCI.0066-09.2009. View

17.

Martin S, Leeman-Markowski B . Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer's disease, and epilepsy. Front Neurol. 2024; 14:1287545. PMC: 10797726. DOI: 10.3389/fneur.2023.1287545. View

18.

Josephson C, Dykeman J, Fiest K, Liu X, Sadler R, Jette N . Systematic review and meta-analysis of standard vs selective temporal lobe epilepsy surgery. Neurology. 2013; 80(18):1669-76. DOI: 10.1212/WNL.0b013e3182904f82. View

19.

Vezzani A . Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?. Expert Opin Drug Saf. 2015; 14(4):583-92. DOI: 10.1517/14740338.2015.1010508. View

20.

Bausch S . Potential roles for hyaluronan and CD44 in kainic acid-induced mossy fiber sprouting in organotypic hippocampal slice cultures. Neuroscience. 2006; 143(1):339-50. DOI: 10.1016/j.neuroscience.2006.07.037. View