Cortical Abnormalities in Epilepsy Revealed by Local EEG Synchrony

Overview

Journal Neuroimage

Specialty Radiology

Date 2007 Jan 17

PMID 17224281

Citations 67

Authors

C A Schevon

J Cappell

R Emerson

J Isler

P Grieve

R Goodman

G McKhann Jr

H Weiner

W Doyle

R Kuzniecky

O Devinsky

F Gilliam

Affiliations

Soon will be listed here.

Abstract

Abnormally strong functional linkage between cortical areas has been postulated to play a role in the pathogenesis of partial epilepsy. We explore the possibility that such linkages may be manifest in the interictal EEG apart from epileptiform disturbances or visually evident focal abnormalities. We analyzed samples of interictal intracranial EEG (ICEEG) recorded from subdural grids in nine patients with medically intractable partial epilepsy, measuring interelectrode synchrony using the mean phase coherence algorithm. This analysis revealed areas of elevated local synchrony, or "hypersynchrony" which had persistent spatiotemporal characteristics that were unique to each patient. Measuring local synchrony in a subdural grid results in a map of the cortical surface that provides information not visually apparent on either EEG or structural imaging. We explore the relationship of hypersynchronous areas to the clinical evidence of seizure localization in each case, and speculate that local hypersynchrony may be a marker of epileptogenic cortex, and may prove to be a valuable aid to clinical ICEEG interpretation.

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References

Chavez M, Le Van Quyen M, Navarro V, Baulac M, Martinerie J . Spatio-temporal dynamics prior to neocortical seizures: amplitude versus phase couplings. IEEE Trans Biomed Eng. 2003; 50(5):571-83. DOI: 10.1109/TBME.2003.810696. View

Lehnertz K, Elger C . Spatio-temporal dynamics of the primary epileptogenic area in temporal lobe epilepsy characterized by neuronal complexity loss. Electroencephalogr Clin Neurophysiol. 1995; 95(2):108-17. DOI: 10.1016/0013-4694(95)00071-6. View

Traub R, Whittington M, Buhl E, LeBeau F, Bibbig A, Boyd S . A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia. 2001; 42(2):153-70. DOI: 10.1046/j.1528-1157.2001.26900.x. View

Valentine P, Teskey G, Eggermont J . Kindling changes burst firing, neural synchrony and tonotopic organization of cat primary auditory cortex. Cereb Cortex. 2004; 14(8):827-39. DOI: 10.1093/cercor/bhh041. View

Paprocka J, Jamroz E, Adamek D, Marszal E, Mandera M . Difficulties in differentiation of Parry-Romberg syndrome, unilateral facial sclerodermia, and Rasmussen syndrome. Childs Nerv Syst. 2005; 22(4):409-15. DOI: 10.1007/s00381-005-1262-x. View

Mormann F, Andrzejak R, Kreuz T, Rieke C, David P, Elger C . Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients. Phys Rev E Stat Nonlin Soft Matter Phys. 2003; 67(2 Pt 1):021912. DOI: 10.1103/PhysRevE.67.021912. View

Guevara R, Perez Velazquez J, Nenadovic V, Wennberg R, Senjanovic G, Dominguez L . Phase synchronization measurements using electroencephalographic recordings: what can we really say about neuronal synchrony?. Neuroinformatics. 2005; 3(4):301-14. DOI: 10.1385/NI:3:4:301. View

Engel Jr J, Wiebe S, French J, Sperling M, Williamson P, Spencer D . Practice parameter: temporal lobe and localized neocortical resections for epilepsy. Epilepsia. 2003; 44(6):741-51. DOI: 10.1046/j.1528-1157.2003.48202.x. View

Towle V, Syed I, Berger C, Grzesczcuk R, Milton J, Erickson R . Identification of the sensory/motor area and pathologic regions using ECoG coherence. Electroencephalogr Clin Neurophysiol. 1998; 106(1):30-9. DOI: 10.1016/s0013-4694(97)00082-5. View

10.

Alarcon G, Binnie C, Elwes R, Polkey C . Power spectrum and intracranial EEG patterns at seizure onset in partial epilepsy. Electroencephalogr Clin Neurophysiol. 1995; 94(5):326-37. DOI: 10.1016/0013-4694(94)00286-t. View

11.

Le Van Quyen M, Soss J, Navarro V, Robertson R, Chavez M, Baulac M . Preictal state identification by synchronization changes in long-term intracranial EEG recordings. Clin Neurophysiol. 2005; 116(3):559-68. DOI: 10.1016/j.clinph.2004.10.014. View

12.

Bragin A, Wilson C, Engel Jr J . Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis. Epilepsia. 2000; 41 Suppl 6:S144-52. DOI: 10.1111/j.1528-1157.2000.tb01573.x. View

13.

Le Van Quyen M, Martinerie J, Navarro V, Baulac And M, Varela F . Characterizing neurodynamic changes before seizures. J Clin Neurophysiol. 2001; 18(3):191-208. DOI: 10.1097/00004691-200105000-00001. View

14.

Asano E, Muzik O, Shah A, Juhasz C, Chugani D, Kagawa K . Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures. Clin Neurophysiol. 2004; 115(12):2718-27. PMC: 1360693. DOI: 10.1016/j.clinph.2004.06.020. View

15.

Dominguez L, Wennberg R, Gaetz W, Cheyne D, Snead 3rd O, Perez Velazquez J . Enhanced synchrony in epileptiform activity? Local versus distant phase synchronization in generalized seizures. J Neurosci. 2005; 25(35):8077-84. PMC: 6725453. DOI: 10.1523/JNEUROSCI.1046-05.2005. View

16.

Jung W, Pacia S, Devinsky O . Neocortical temporal lobe epilepsy: intracranial EEG features and surgical outcome. J Clin Neurophysiol. 1999; 16(5):419-25. DOI: 10.1097/00004691-199909000-00003. View

17.

Blumenfeld H, McNally K, Vanderhill S, Paige A, Chung R, Davis K . Positive and negative network correlations in temporal lobe epilepsy. Cereb Cortex. 2004; 14(8):892-902. DOI: 10.1093/cercor/bhh048. View

18.

Quesney L, Constain M, Rasmussen T, Stefan H, Olivier A . How large are frontal lobe epileptogenic zones? EEG, ECoG, and SEEG evidence. Adv Neurol. 1992; 57:311-23. View

19.

Worrell G, Parish L, Cranstoun S, Jonas R, Baltuch G, Litt B . High-frequency oscillations and seizure generation in neocortical epilepsy. Brain. 2004; 127(Pt 7):1496-506. DOI: 10.1093/brain/awh149. View

20.

Towle V, Carder R, Khorasani L, Lindberg D . Electrocorticographic coherence patterns. J Clin Neurophysiol. 1999; 16(6):528-47. DOI: 10.1097/00004691-199911000-00005. View