Preoperative Low Creatine Kinase As a Poor Prognostic Factor in Patients with Colorectal Cancer

Overview

Journal J Gastrointest Cancer

Publisher Springer

Specialties Gastroenterology
Oncology

Date 2024 Jun 13

PMID 38869820

Authors

Mitsunori Ushigome

Hideaki Shimada

Tomoaki Kaneko

Yasuyuki Miura

Kimihiko Yoshida

Takayuki Suzuki

Satoru Kagami

Akiharu Kurihara

Kimihiko Funahashi

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to evaluate the clinicopathological and prognostic significance of preoperative serum creatine kinase (CK) levels in colorectal cancer.

Methods: This study analyzed 1169 patients with colorectal cancer at stages 0 (n = 35), I (n = 301), II (n = 456), III (n = 339), and IV (n = 38). The CK cut-off value was 52 U/L to predict recurrence based on receiver operative characteristics curve. Clinicopathological factors were compared between the low (< 52 U/L) and high CK groups (≥ 52 U/L). The multivariate analysis evaluated relapse-free survival (RFS) and overall survival (OS) following CK status.

Results: The female sex, elderly age (≥ 75), deep tumor (pT4), and carcinoembryonic antigen (+) were independently associated with low CK status. The recurrent rate was significantly higher in the low CK group than in the high CK group (19.1% vs. 11.7%, p < 0.001). Elderly age, pT4, pN (+), preoperative carbohydrate antigen (CA) 19-9 (+), and low CK status were independent risk factors for RFS. Elderly age, pT4, pN (+), preoperative CA19-9 (+), and low CK status were independent risk factors for OS.

Conclusion: Preoperative low CK status was associated with deep tumors and was a poor prognostic factor in patients with colorectal cancer.

Citing Articles

It Is Not Just About Storing Energy: The Multifaceted Role of Creatine Metabolism on Cancer Biology and Immunology.

Geng Y, DeLay S, Chen X, Miska J Int J Mol Sci. 2025; 25(24).

PMID: 39769038 PMC: 11678534. DOI: 10.3390/ijms252413273.

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