» Articles » PMID: 23208313

Investigation of the Freely Available Easy-to-use Software 'EZR' for Medical Statistics

Overview
Specialty General Surgery
Date 2012 Dec 5
PMID 23208313
Citations 6351
Authors
Affiliations
Soon will be listed here.
Abstract

Although there are many commercially available statistical software packages, only a few implement a competing risk analysis or a proportional hazards regression model with time-dependent covariates, which are necessary in studies on hematopoietic SCT. In addition, most packages are not clinician friendly, as they require that commands be written based on statistical languages. This report describes the statistical software 'EZR' (Easy R), which is based on R and R commander. EZR enables the application of statistical functions that are frequently used in clinical studies, such as survival analyses, including competing risk analyses and the use of time-dependent covariates, receiver operating characteristics analyses, meta-analyses, sample size calculation and so on, by point-and-click access. EZR is freely available on our website (http://www.jichi.ac.jp/saitama-sct/SaitamaHP.files/statmed.html) and runs on both Windows (Microsoft Corporation, USA) and Mac OS X (Apple, USA). This report provides instructions for the installation and operation of EZR.

Citing Articles

Favorable outcomes of de novo advanced phases of pediatric chronic myeloid leukemia in the tyrosine kinase inhibitor era.

Yoshikawa T, Ishida H, Watanabe A, Yuza Y, Shima H, Ito M Int J Hematol. 2025; .

PMID: 40088374 DOI: 10.1007/s12185-025-03953-x.


Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells.

Watanabe H, Inoue Y, Tsuchiya K, Asada K, Suzuki M, Ogawa H NPJ Precis Oncol. 2025; 9(1):74.

PMID: 40082639 PMC: 11906894. DOI: 10.1038/s41698-025-00860-6.


Isoschaftoside in Fig Leaf Tea Alleviates Nonalcoholic Fatty Liver Disease in Mice via the Regulation of Macrophage Polarity.

Abe T Nutrients. 2025; 17(5).

PMID: 40077628 PMC: 11902273. DOI: 10.3390/nu17050757.


MRI-Guided Multi-Catheter High-Dose-Rate Interstitial Brachytherapy for Uterine Cervical Cancer.

Yamazaki H, Masui K, Yoshida K, Suzuki G, Takenaka T, Yamada K Cancers (Basel). 2025; 17(5).

PMID: 40075617 PMC: 11899140. DOI: 10.3390/cancers17050770.


Skim Milk Culture of SBT0309 Increases Intestinal Alkaline Phosphatase Activity and Inhibits Lipopolysaccharide-Induced Interleukin-8 Production in Intestinal Epithelial Cells.

Kawano M, Arai T, Kabuki T Cells. 2025; 14(5).

PMID: 40072089 PMC: 11898809. DOI: 10.3390/cells14050358.


References
1.
Dignam J, Kocherginsky M . Choice and interpretation of statistical tests used when competing risks are present. J Clin Oncol. 2008; 26(24):4027-34. PMC: 2654314. DOI: 10.1200/JCO.2007.12.9866. View

2.
Klein J, Rizzo J, Zhang M, Keiding N . Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part 2: Regression modeling. Bone Marrow Transplant. 2002; 28(11):1001-11. DOI: 10.1038/sj.bmt.1703271. View

3.
Klein J, Andersen P . Regression modeling of competing risks data based on pseudovalues of the cumulative incidence function. Biometrics. 2005; 61(1):223-9. DOI: 10.1111/j.0006-341X.2005.031209.x. View

4.
Scrucca L, Santucci A, Aversa F . Competing risk analysis using R: an easy guide for clinicians. Bone Marrow Transplant. 2007; 40(4):381-7. DOI: 10.1038/sj.bmt.1705727. View

5.
Klein J, Rizzo J, Zhang M, Keiding N . Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part I: unadjusted analysis. Bone Marrow Transplant. 2001; 28(10):909-15. DOI: 10.1038/sj.bmt.1703260. View