Impact of Tobacco Smoking on Oral Cancer Genetics-A Next-generation Sequencing Perspective

Overview

Journal Imeta

Specialty Biology

Date 2024 Jun 13

PMID 38868711

Authors

Vishwas Sharma

Dinesh Kumar

Shravan Kumar

Harpreet Singh

Naveen Sharma

Sanjay Gupta

Affiliations

Soon will be listed here.

Abstract

This study identified a total of 28 genetic loci (comprising 31 genes), which were found to be altered in oral cancer patients having a habit of tobacco smoking. Three loci, that is, 17p13.1 (), 9p21.3 (), and 9q34.3 () were found to be modified and common in three records whereas one locus, that is, 3q26.32 () was found to be modified and common in two records. This study suggests that oral cancer patients should be categorized into different subgroups based on (i) genetic signatures, and (ii) smoking status, then the treatment strategies for each group should be precisely defined.

Citing Articles

Salivary cysteine levels as a potential biochemical indicator of oral cancer risk in tobacco consumers.

Vats R, Yadav P, Bano A, Wadhwa S, Narwal A, Bhardwaj R Biomark Med. 2024; 18(20):877-888.

PMID: 39344869 PMC: 11508954. DOI: 10.1080/17520363.2024.2403327.

Impact of tobacco smoking on oral cancer genetics-A next-generation sequencing perspective.

Sharma V, Kumar D, Kumar S, Singh H, Sharma N, Gupta S Imeta. 2024; 1(3):e44.

PMID: 38868711 PMC: 10989814. DOI: 10.1002/imt2.44.

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