Effect of Off-Season Iron Supplementation on Aerobic Capacity of Female Handball Player: A Randomized, Double-Blinded, Placebo-Controlled Study

Overview

Journal Curr Dev Nutr

Specialty Nutritional Sciences

Date 2024 Jun 13

PMID 38868615

Authors

Ghazal Safa

Mohammad Hemmatinafar

Javad Nemati

Babak Imanian

Katsuhiko Suzuki

Affiliations

Soon will be listed here.

Abstract

Background: Iron supplementation, especially in female athletes, is 1 of the influential factors in aerobic capacity, and its deficiency can lead to significant problems related to reduced aerobic capacity.

Objectives: This study aimed to investigate the effect of 3 wk of iron supplementation on the aerobic capacity of female handball players.

Methods: In this randomized double-blinded, and placebo control trial, 14 elite handball players (age: 21.6 ± 5.68 y; height: 169.5 ± 4.9 cm; weight: 62.2 ± 9.25 kg; body mass index (in kg/m): 21.5 ± 2.9) randomly divided into 2 supplement groups (receiving a 100 mg/d of poly-maltose tri hydroxide iron complex in the form of tablets) and the placebo group (receiving a tablet containing 100 mg/d starch which is the same color and shape as iron tablets). The supplementation protocol was performed for 3 wk during the off-season. Maximal oxygen consumption (VO), amounts of carbon dioxide at the first ventilatory threshold, amounts of carbon dioxide at the second ventilatory threshold, time to exhaustion (TTE), pulmonary ventilation (VE), ventilatory equivalents for oxygen, amounts of oxygen at the first ventilatory threshold, amounts of oxygen at the second ventilatory threshold, time to reach first ventilatory threshold, end-tidal partial pressure of oxygen at the first ventilatory threshold, end-tidal partial pressure of carbon dioxide at the first ventilatory threshold and ventilatory equivalents for carbon dioxide were measured using the Bruce test and gas analyzer in 2 pretest and posttest stages.

Results: There were significant improvements in oxygen at the first ventilatory threshold, time to reach first ventilatory threshold, and end-tidal partial pressure of carbon dioxide at the first ventilatory threshold and a significant decrease in end-tidal partial pressure of oxygen at the first ventilatory threshold ( < 0.05). Also, no significant changes were found in VO, carbon dioxide at the first ventilatory threshold, carbon dioxide at the second ventilatory threshold, oxygen at the second ventilatory threshold, TTE, VE, ventilatory equivalents for oxygen, and ventilatory equivalents for carbon dioxide after 3 wk of iron supplementation ( > 0.05).

Conclusions: The study found that 3 wk of off-season iron supplementation positively impacted female handball players' aerobic capacity; however, it did not significantly improve their VO.

References

Cordova A, Mielgo-Ayuso J, Fernandez-Lazaro C, Caballero-Garcia A, Roche E, Fernandez-Lazaro D . Effect of Iron Supplementation on the Modulation of Iron Metabolism, Muscle Damage Biomarkers and Cortisol in Professional Cyclists. Nutrients. 2019; 11(3). PMC: 6470682. DOI: 10.3390/nu11030500. View

Skarpanska-Stejnborn A, Basta P, Trzeciak J, Szczesniak-Pilaczynska L . Effect of intense physical exercise on hepcidin levels and selected parameters of iron metabolism in rowing athletes. Eur J Appl Physiol. 2014; 115(2):345-51. PMC: 4289533. DOI: 10.1007/s00421-014-3018-3. View

Sue D, Wasserman K, Moricca R, Casaburi R . Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease. Use of the V-slope method for anaerobic threshold determination. Chest. 1988; 94(5):931-8. DOI: 10.1378/chest.94.5.931. View

Czuba M, Waskiewicz Z, Zajac A, Poprzecki S, Cholewa J, Roczniok R . The effects of intermittent hypoxic training on aerobic capacity and endurance performance in cyclists. J Sports Sci Med. 2013; 10(1):175-83. PMC: 3737917. View

Balady G, Arena R, Sietsema K, Myers J, Coke L, Fletcher G . Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation. 2010; 122(2):191-225. DOI: 10.1161/CIR.0b013e3181e52e69. View

Kuwabara A, Tenforde A, Finnoff J, Fredericson M . Iron deficiency in athletes: A narrative review. PM R. 2022; 14(5):620-642. DOI: 10.1002/pmrj.12779. View

Wang J, Huo J, Sun J, Ning Z . Physical performance of migrant schoolchildren with marginal and severe iron deficiency in the suburbs of Beijing. Biomed Environ Sci. 2009; 22(4):333-9. DOI: 10.1016/S0895-3988(09)60064-7. View

Rubeor A, Goojha C, Manning J, White J . Does Iron Supplementation Improve Performance in Iron-Deficient Nonanemic Athletes?. Sports Health. 2018; 10(5):400-405. PMC: 6116100. DOI: 10.1177/1941738118777488. View

Clement D, Asmundson R . Nutritional Intake and Hematological Parameters in Endurance Runners. Phys Sportsmed. 2017; 10(3):37-43. DOI: 10.1080/00913847.1982.11947181. View

10.

LaManca J, Haymes E . Effects of iron repletion on VO2max, endurance, and blood lactate in women. Med Sci Sports Exerc. 1993; 25(12):1386-92. View

11.

Klingshirn L, Pate R, Bourque S, Davis J, Sargent R . Effect of iron supplementation on endurance capacity in iron-depleted female runners. Med Sci Sports Exerc. 1992; 24(7):819-24. View

12.

Nemati J, Hemmatinafar M, Niknam A, Nikahd M, Zeighami N, Imanian B . Effects of Different Doses of Caffeine Supplementation on Collegiate Male Volleyball Players' Specific Performance and Skills: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Nutrients. 2023; 15(18). PMC: 10536286. DOI: 10.3390/nu15184049. View

13.

Beck K, Thomson J, Swift R, von Hurst P . Role of nutrition in performance enhancement and postexercise recovery. Open Access J Sports Med. 2015; 6:259-67. PMC: 4540168. DOI: 10.2147/OAJSM.S33605. View

14.

Friedmann B, Jost J, Rating T, Weller E, Werle E, Eckardt K . Effects of iron supplementation on total body hemoglobin during endurance training at moderate altitude. Int J Sports Med. 1999; 20(2):78-85. DOI: 10.1055/s-2007-971097. View

15.

Falsetti H, Burke E, Feld R, Frederick E, Ratering C . Hematological Variations After Endurance Running With Hard-and Soft-Soled Running Shoes. Phys Sportsmed. 2016; 11(8):118-27. DOI: 10.1080/00913847.1983.11708609. View

16.

Brownlie 4th T, Utermohlen V, Hinton P, Giordano C, Haas J . Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. Am J Clin Nutr. 2002; 75(4):734-42. DOI: 10.1093/ajcn/75.4.734. View

17.

Brutsaert T, Hernandez-Cordero S, Rivera J, Viola T, Hughes G, Haas J . Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. Am J Clin Nutr. 2003; 77(2):441-8. DOI: 10.1093/ajcn/77.2.441. View

18.

Means R . Hepcidin and cytokines in anaemia. Hematology. 2005; 9(5-6):357-62. DOI: 10.1080/10245330400018540. View

19.

Pirmohammadi S, Hemmatinafar M, Nemati J, Imanian B, Abdollahi M . Early absorption sources of caffeine can be a useful strategy for improving female table tennis players-specific performance. J Int Soc Sports Nutr. 2023; 20(1):2282051. PMC: 11018319. DOI: 10.1080/15502783.2023.2282051. View

20.

Jeukendrup A . A step towards personalized sports nutrition: carbohydrate intake during exercise. Sports Med. 2014; 44 Suppl 1:S25-33. PMC: 4008807. DOI: 10.1007/s40279-014-0148-z. View