A Deep Learning-based Automated Diagnosis System for SPECT Myocardial Perfusion Imaging
Authors
Affiliations
Images obtained from single-photon emission computed tomography for myocardial perfusion imaging (MPI SPECT) contain noises and artifacts, making cardiovascular disease diagnosis difficult. We developed a deep learning-based diagnosis support system using MPI SPECT images. Single-center datasets of MPI SPECT images (n = 5443) were obtained and labeled as healthy or coronary artery disease based on diagnosis reports. Three axes of four-dimensional datasets, resting, and stress conditions of three-dimensional reconstruction data, were reconstructed, and an AI model was trained to classify them. The trained convolutional neural network showed high performance [area under the curve (AUC) of the ROC curve: approximately 0.91; area under the recall precision curve: 0.87]. Additionally, using unsupervised learning and the Grad-CAM method, diseased lesions were successfully visualized. The AI-based automated diagnosis system had the highest performance (88%), followed by cardiologists with AI-guided diagnosis (80%) and cardiologists alone (65%). Furthermore, diagnosis time was shorter for AI-guided diagnosis (12 min) than for cardiologists alone (31 min). Our high-quality deep learning-based diagnosis support system may benefit cardiologists by improving diagnostic accuracy and reducing working hours.
Alenezi A, Mayya A, Alajmi M, Almutairi W, Alaradah D, Alhamad H Diagnostics (Basel). 2025; 14(24.
PMID: 39767226 PMC: 11675551. DOI: 10.3390/diagnostics14242865.
Hu X, Zhang H, Caobelli F, Huang Y, Li Y, Zhang J iScience. 2024; 27(12):111374.
PMID: 39654634 PMC: 11626733. DOI: 10.1016/j.isci.2024.111374.