Activity of Taurolidine Against Clinical Isolates: Relevance to Catheter-related Bloodstream Infections

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2024 Jun 12

PMID 38864612

Authors

Bruce E Reidenberg

Stephen G Jenkins

Jared L Crandon

Elizabeth Hurlburt

Xing Tan

Paul R Rhomberg

S J Ryan Arends

Antony Pfaffle

Affiliations

Soon will be listed here.

Abstract

is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 . isolates. Taurolidine was highly active with a MIC/MIC of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of catheter-associated infections.

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