The Relationship Between Coronavirus Disease-19 (COVID-19) and Ischemic Priapism: a Case-control Study

Overview

Journal Int J Impot Res

Specialties Reproductive Medicine
Urology

Date 2024 Jun 11

PMID 38862624

Authors

Khaled Almekaty

Ahmed E Taha

Maged Ragab

Ibrahim M Ibrahim

Ayman Rashed

Ahmed Eid

Amr Moubasher

Mohamed H Zahran

Affiliations

Soon will be listed here.

Abstract

This multicentre retrospective study was conducted in 3 university hospitals in Egypt between April 2020 and June 2022. The aim was to assess the relation between Coronavirus Disease-19 (COVID-19) and ischemic priapism. Forty-three ischemic priapism patients were diagnosed and divided into two groups (30 in group I with ischemic priapism only, and 13 in group II with both ischemic priapism and COVID-19). Further sub-classification of COVID-19 patients according to the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection severity was done. Cavernosal aspiration was successful in 25 patients (83.3%) in group I and 12 (92.3%) in group II. Long term follow-up proved moderate to severe erectile dysfunction in 6 patients (20.0%) and 1 (7.7%) in group I and II, respectively. All those with severe erectile dysfunction were managed by distal shunt and prepared for penile prosthesis placement. The median duration of ischemic priapism was significantly longer in patients with severe erectile dysfunction [19 vs. 7 h, P = 0.01]. There was no statistically significant difference between both groups regarding patients' age (p = 0.8), required priapism management (p = 0.4), priapism recurrence (p = 0.1), and erectile dysfunction severity (p = 0.5). Ischemic priapism in COVID-19 patients can occur not only in severe, but also in mild or even asymptomatic cases. COVID-19 did not influence the ischemic priapism treatment protocol and post-treatment erectile function. COVID-19 and ischemic priapism seem to have a coincidence relation rather than a causal.

References

Puliatti S, Eissa A, Eissa R, Amato M, Mazzone E, Delloglio P . COVID-19 and urology: a comprehensive review of the literature. BJU Int. 2020; 125(6):E7-E14. DOI: 10.1111/bju.15071. View

Khamis A, Jaber M, Azar A, Alqahtani F, Bishawi K, Shanably A . Clinical and laboratory findings of COVID-19: A systematic review and meta-analysis. J Formos Med Assoc. 2020; 120(9):1706-1718. PMC: 7832677. DOI: 10.1016/j.jfma.2020.12.003. View

Malas M, Naazie I, Elsayed N, Mathlouthi A, Marmor R, Clary B . Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: A systematic review and meta-analysis. EClinicalMedicine. 2020; 29:100639. PMC: 7679115. DOI: 10.1016/j.eclinm.2020.100639. View

Mumm J, Osterman A, Ruzicka M, Stihl C, Vilsmaier T, Munker D . Urinary Frequency as a Possibly Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis?. Eur Urol. 2020; 78(4):624-628. PMC: 7236674. DOI: 10.1016/j.eururo.2020.05.013. View

Spycher M, Hauri D . The ultrastructure of the erectile tissue in priapism. J Urol. 1986; 135(1):142-7. DOI: 10.1016/s0022-5347(17)45549-2. View

Malinga D, Laher A, McDowall J, Adam A . Coronavirus disease 2019 (COVID-19) and priapism: An unexplored association. Curr Urol. 2022; 16(2):55-62. PMC: 9245531. DOI: 10.1097/CU9.0000000000000111. View

Prokop M, van Everdingen W, van Rees Vellinga T, Quarles van Ufford H, Stoger L, Beenen L . CO-RADS: A Categorical CT Assessment Scheme for Patients Suspected of Having COVID-19-Definition and Evaluation. Radiology. 2020; 296(2):E97-E104. PMC: 7233402. DOI: 10.1148/radiol.2020201473. View

Rosen R, Cappelleri J, Smith M, Lipsky J, Pena B . Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 2000; 11(6):319-26. DOI: 10.1038/sj.ijir.3900472. View

Shamloul R, Ghanem H, Abou-Zeid A . Validity of the Arabic version of the sexual health inventory for men among Egyptians. Int J Impot Res. 2004; 16(5):452-5. DOI: 10.1038/sj.ijir.3901248. View

10.

Sheikhzadeh Hesari F, Hosseinzadeh S, Asl Monadi Sardroud M . Review of COVID-19 and male genital tract. Andrologia. 2020; 53(1):e13914. PMC: 7744899. DOI: 10.1111/and.13914. View

11.

Lamamri M, Chebbi A, Mamane J, Abbad S, Munuzzolini M, Sarfati F . Priapism in a patient with coronavirus disease 2019 (COVID-19). Am J Emerg Med. 2020; 39:251.e5-251.e7. PMC: 7301054. DOI: 10.1016/j.ajem.2020.06.027. View

12.

Lam G, McCarthy R, Haider R . A Peculiar Case of Priapism: The Hypercoagulable State in Patients with Severe COVID-19 Infection. Eur J Case Rep Intern Med. 2020; 7(8):001779. PMC: 7417049. DOI: 10.12890/2020_001779. View

13.

Silverman M, VanDerVeer S, Donnelly T . Priapism in COVID-19: A thromboembolic complication. Am J Emerg Med. 2021; 45:686.e5-686.e6. PMC: 7775653. DOI: 10.1016/j.ajem.2020.12.072. View

14.

Piazza G, Morrow D . Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19. JAMA. 2020; 324(24):2548-2549. DOI: 10.1001/jama.2020.23422. View

15.

Mondal S, Quintili A, Karamchandani K, Bose S . Thromboembolic disease in COVID-19 patients: A brief narrative review. J Intensive Care. 2020; 8:70. PMC: 7487447. DOI: 10.1186/s40560-020-00483-y. View

16.

Katz E, Politano V, Scandiffio M . Priapism: an unusual complication of parotitis without orchitis. J Urol. 1976; 115(5):613. DOI: 10.1016/s0022-5347(17)59305-2. View

17.

Mui L, Lau J, Lee H . Thromboembolic complications of COVID-19. Emerg Radiol. 2020; 28(2):423-429. PMC: 7647885. DOI: 10.1007/s10140-020-01868-0. View

18.

Alharthy A, Balhamar A, Faqihi F, Alshaya R, Noor A, Alaklobi F . Insidious development of pulmonary embolism in asymptomatic patients with COVID-19: Two rare case-reports. Respir Med Case Rep. 2020; 31:101186. PMC: 7418650. DOI: 10.1016/j.rmcr.2020.101186. View

19.

Chen B, Jiang C, Han B, Guan C, Fang G, Yan S . High prevalence of occult thrombosis in cases of mild/moderate COVID-19. Int J Infect Dis. 2020; 104:77-82. PMC: 7749732. DOI: 10.1016/j.ijid.2020.12.042. View

20.

Taboada M, Gonzalez M, Alvarez A, Eiras M, Costa J, Alvarez J . First, second and third wave of COVID-19. What have we changed in the ICU management of these patients?. J Infect. 2021; 82(6):e14-e15. PMC: 8019402. DOI: 10.1016/j.jinf.2021.03.027. View