Astronaut Omics and the Impact of Space on the Human Body at Scale

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Jun 11

PMID 38862505

Authors

Lindsay A Rutter

Henry Cope

Matthew J MacKay

Raul Herranz

Saswati Das

Sergey A Ponomarev

Sylvain V Costes

Amber M Paul

Richard Barker

Deanne M Taylor

Daniela Bezdan

Nathaniel J Szewczyk

Masafumi Muratani

Christopher E Mason

Stefania Giacomello

Affiliations

Soon will be listed here.

Abstract

Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in the human body. Here, we propose that a parallel Human Cell Space Atlas could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit could permit an advent of precision spaceflight healthcare. Alongside the scientific potential, we consider the complex ethical, cultural, and legal challenges intrinsic to the human space omics discipline, and how philosophical frameworks may benefit from international perspectives.

Citing Articles

Protective alleles and precision healthcare in crewed spaceflight.

Rutter L, MacKay M, Cope H, Szewczyk N, Kim J, Overbey E Nat Commun. 2024; 15(1):6158.

PMID: 39039045 PMC: 11263583. DOI: 10.1038/s41467-024-49423-6.

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).

Overbey E, Ryon K, Kim J, Tierney B, Klotz R, Ortiz V Nat Commun. 2024; 15(1):4964.

PMID: 38862509 PMC: 11166662. DOI: 10.1038/s41467-024-48806-z.

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses.

Grigorev K, Nelson T, Overbey E, Houerbi N, Kim J, Najjar D Nat Commun. 2024; 15(1):4950.

PMID: 38862496 PMC: 11166648. DOI: 10.1038/s41467-024-48929-3.

A second space age spanning omics, platforms and medicine across orbits.

Mason C, Green J, Adamopoulos K, Afshin E, Baechle J, Basner M Nature. 2024; 632(8027):995-1008.

PMID: 38862027 DOI: 10.1038/s41586-024-07586-8.

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight.

Garcia-Medina J, Sienkiewicz K, Narayanan S, Overbey E, Grigorev K, Ryon K Precis Clin Med. 2024; 7(1):pbae007.

PMID: 38634106 PMC: 11022651. DOI: 10.1093/pcmedi/pbae007.

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