Effects of MiR-29c on Proliferation and Adipogenic Differentiation of Porcine Bone Marrow Mesenchymal Stromal Cells

Overview

Journal Adipocyte

Specialties Cell Biology
Endocrinology
Physiology

Date 2024 Jun 11

PMID 38858810

Authors

Anjing Zhang

Lu Lu

Fuxing Yang

Tingting Luo

Shuqi Yang

Peidong Yang

Xuemin Li

Xiaoli Deng

Yang Qiu

Litong Chen

Keren Long

Dengke Pan

Long Jin

Mingzhou Li

Li Chen

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNAs), a subclass of noncoding short RNAs, direct cells fate decisions that are important for cell proliferation and cell lineage decisions. Adipogenic differentiation contributes greatly to the development of white adipose tissue, involving of highly organized regulation by miRNAs. In the present study, we screened and identified 78 differently expressed miRNAs of porcine BMSCs during adipogenic differentiation. Of which, the role of miR-29c in regulating the proliferation and adipogenic differentiation was proved and detailed. Specifically, over-expression miR-29c inhibits the proliferation and adipogenic differentiation of BMSCs, which were reversed upon miR-29c inhibitor. Interference of inhibits the proliferation and adipogenic differentiation of BMSCs. Mechanistically, miR-29c regulates the proliferation and adipogenic differentiation of BMSCs by targeting IGF1 and further regulating the MAPK pathway and the PI3K-AKT-mTOR pathway, respectively. In conclusion, we highlight the important role of miR-29c in regulating proliferation and adipogenic differentiation of BMSCs.

Citing Articles

MicroRNAs and their Modulatory Effect on the Hallmarks of Osteosarcopenia.

Silva W, Cruz A, Duque G Curr Osteoporos Rep. 2024; 22(5):458-470.

PMID: 39162945 DOI: 10.1007/s11914-024-00880-4.

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