Manipulating Calcium Homeostasis with Nanoplatforms for Enhanced Cancer Therapy

Overview

Journal Exploration (Beijing)

Specialty Biomedical Engineering

Date 2024 Jun 10

PMID 38854493

Authors

Yanlin Feng

Jianlin Wang

Jimin Cao

Fangfang Cao

Xiaoyuan Chen

Affiliations

Soon will be listed here.

Abstract

Calcium ions (Ca) are indispensable and versatile metal ions that play a pivotal role in regulating cell metabolism, encompassing cell survival, proliferation, migration, and gene expression. Aberrant Ca levels are frequently linked to cell dysfunction and a variety of pathological conditions. Therefore, it is essential to maintain Ca homeostasis to coordinate body function. Disrupting the balance of Ca levels has emerged as a potential therapeutic strategy for various diseases, and there has been extensive research on integrating this approach into nanoplatforms. In this review, the current nanoplatforms that regulate Ca homeostasis for cancer therapy are first discussed, including both direct and indirect approaches to manage Ca overload or inhibit Ca signalling. Then, the applications of these nanoplatforms in targeting different cells to regulate their Ca homeostasis for achieving therapeutic effects in cancer treatment are systematically introduced, including tumour cells and immune cells. Finally, perspectives on the further development of nanoplatforms for regulating Ca homeostasis, identifying scientific limitations and future directions for exploitation are offered.

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References

Zhu J, Jiao A, Li Q, Lv X, Wang X, Song X . Mitochondrial Ca-overloading by oxygen/glutathione depletion-boosted photodynamic therapy based on a CaCO nanoplatform for tumor synergistic therapy. Acta Biomater. 2021; 137:252-261. DOI: 10.1016/j.actbio.2021.10.016. View

Zhang S, Cao C, Lv X, Dai H, Zhong Z, Liang C . A HO self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy. Chem Sci. 2021; 11(7):1926-1934. PMC: 8148300. DOI: 10.1039/c9sc05506a. View

Mayerhofer M, Gleixner K, Mayerhofer J, Hoermann G, Jaeger E, Aichberger K . Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood. 2007; 111(4):2200-10. DOI: 10.1182/blood-2006-11-055723. View

Gardner A, Ruffell B . Dendritic Cells and Cancer Immunity. Trends Immunol. 2016; 37(12):855-865. PMC: 5135568. DOI: 10.1016/j.it.2016.09.006. View

Sun S, Liu X, Zou W, Yue P, Marcus A, Khuri F . The farnesyltransferase inhibitor lonafarnib induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells. J Biol Chem. 2007; 282(26):18800-9. DOI: 10.1074/jbc.M611438200. View

Sharma R, Gescher A, Steward W . Curcumin: the story so far. Eur J Cancer. 2005; 41(13):1955-68. DOI: 10.1016/j.ejca.2005.05.009. View

Feng Y, Wang J, Cao J, Cao F, Chen X . Manipulating calcium homeostasis with nanoplatforms for enhanced cancer therapy. Exploration (Beijing). 2024; 4(1):20230019. PMC: 10867402. DOI: 10.1002/EXP.20230019. View

Xu L, Wang X, Wang W, Sun M, Choi W, Kim J . Enantiomer-dependent immunological response to chiral nanoparticles. Nature. 2022; 601(7893):366-373. DOI: 10.1038/s41586-021-04243-2. View

Kong F, Garcia A, Mould A, Humphries M, Zhu C . Demonstration of catch bonds between an integrin and its ligand. J Cell Biol. 2009; 185(7):1275-84. PMC: 2712956. DOI: 10.1083/jcb.200810002. View

10.

Tian Z, Zhao J, Zhao S, Li H, Guo Z, Liang Z . Phytic acid-modified CeO as Ca inhibitor for a security reversal of tumor drug resistance. Nano Res. 2022; 15(5):4334-4343. PMC: 8800414. DOI: 10.1007/s12274-022-4069-0. View

11.

Cardenas C, Muller M, McNeal A, Lovy A, Jana F, Bustos G . Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria. Cell Rep. 2016; 14(10):2313-24. PMC: 4794382. DOI: 10.1016/j.celrep.2016.02.030. View

12.

Favaro G, Romanello V, Varanita T, Desbats M, Morbidoni V, Tezze C . DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass. Nat Commun. 2019; 10(1):2576. PMC: 6561930. DOI: 10.1038/s41467-019-10226-9. View

13.

Lin Y, Wang X, Huang X, Zhang J, Xia N, Zhao Q . Calcium phosphate nanoparticles as a new generation vaccine adjuvant. Expert Rev Vaccines. 2017; 16(9):895-906. DOI: 10.1080/14760584.2017.1355733. View

14.

Bao W, Liu M, Meng J, Liu S, Wang S, Jia R . MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload. Nat Commun. 2021; 12(1):6399. PMC: 8569165. DOI: 10.1038/s41467-021-26655-4. View

15.

Wang Y, Tsai S, Chen M, Hsieh F, Chang Y, Tung F . Mineral Nanomedicine to Enhance the Efficacy of Adjuvant Radiotherapy for Treating Osteosarcoma. ACS Appl Mater Interfaces. 2022; 14(4):5586-5597. DOI: 10.1021/acsami.1c21729. View

16.

Monteith G, Prevarskaya N, Roberts-Thomson S . The calcium-cancer signalling nexus. Nat Rev Cancer. 2017; 17(6):367-380. DOI: 10.1038/nrc.2017.18. View

17.

Dong Z, Feng L, Hao Y, Chen M, Gao M, Chao Y . Synthesis of Hollow Biomineralized CaCO-Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity. J Am Chem Soc. 2018; 140(6):2165-2178. DOI: 10.1021/jacs.7b11036. View

18.

Xu M, Zhang J, Mu Y, Foda M, Han H . Activation of TRPV1 by capsaicin-loaded CaCO nanoparticle for tumor-specific therapy. Biomaterials. 2022; 284:121520. DOI: 10.1016/j.biomaterials.2022.121520. View

19.

Delierneux C, Kouba S, Shanmughapriya S, Potier-Cartereau M, Trebak M, Hempel N . Mitochondrial Calcium Regulation of Redox Signaling in Cancer. Cells. 2020; 9(2). PMC: 7072435. DOI: 10.3390/cells9020432. View

20.

Zhao H, Wang L, Zeng K, Li J, Chen W, Liu Y . Nanomessenger-Mediated Signaling Cascade for Antitumor Immunotherapy. ACS Nano. 2021; 15(8):13188-13199. DOI: 10.1021/acsnano.1c02765. View