Enhanced Long-term Potentiation in the Anterior Cingulate Cortex of Tree Shrew

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2024 Jun 10

PMID 38853555

Authors

Qian Song

Xu-hui Li

Jing-Shan Lu

Qi-Yu Chen

Ren-Hao Liu

Si-Bo Zhou

Min Zhuo

Affiliations

Soon will be listed here.

Abstract

Synaptic plasticity is a key cellular model for learning, memory and chronic pain. Most previous studies were carried out in rats and mice, and less is known about synaptic plasticity in non-human primates. In the present study, we used integrative experimental approaches to study long-term potentiation (LTP) in the anterior cingulate cortex (ACC) of adult tree shrews. We found that glutamate is the major excitatory transmitter and α-amino-3-hydroxy-5-methyl-4-isoxazole-propionicacid (AMPA) receptors mediate postsynaptic responses. LTP in tree shrews was greater than that in adult mice and lasted for at least 5 h. -methyl-d-aspartic acid (NMDA) receptors, Ca influx and adenylyl cyclase 1 (AC1) contributed to tree shrew LTP. Our results suggest that LTP is a major form of synaptic plasticity in the ACC of primate-like animals. This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'.

Citing Articles

Long-term potentiation: 50 years on: past, present and future.

Abraham W, Bliss T, Collingridge G, Morris R Philos Trans R Soc Lond B Biol Sci. 2024; 379(1906):20230218.

PMID: 38853569 PMC: 11343267. DOI: 10.1098/rstb.2023.0218.

Enhanced long-term potentiation in the anterior cingulate cortex of tree shrew.

Song Q, Li X, Lu J, Chen Q, Liu R, Zhou S Philos Trans R Soc Lond B Biol Sci. 2024; 379(1906):20230240.

PMID: 38853555 PMC: 11343311. DOI: 10.1098/rstb.2023.0240.

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