The Effect of LNCRNA SHANK3 on the Malignant Development of Gastric Cancer Cells by Regulating the MiR-4530/MNX1

Overview

Journal Transl Oncol

Specialty Oncology

Date 2024 Jun 9

PMID 38852278

Authors

Li-Li Zhao

Yuan Xiang

Jin-Xuan Wang

Chao Shen

Hui Liu

Qi-Bei Zong

Hui-Min Zhang

Jia-Peng Li

Cong Wang

Fan Sun

Xing-Hua Liao

Affiliations

Soon will be listed here.

Abstract

Gastric cancer (GC) has become the first malignant tumor with highest incidence rate and mortality of cancer in China, finding therapeutic targets for gastric cancer is of great significant for improving the survival rate of patients with GC. Recently, many of studies have shown that LncRNAs is involved in multiple biological progresses in the development of GC. This study, we screened for abnormally high expression of LncSHANK3 in GC through the TCGA database, and found that LncSHANK3 sponge adsorbs miR-4530, further competing with MNX1 and binding to miR-4530. We demonstrated the interaction between LncSHANK3 and miR-4530 through luciferase reporting analysis, with miR-4530 negatively regulating MNX1.Through CCK8, colony formation, transwell, and wound healing assays, it was found that LncSHANK3 affects the occurrence of GC through cell proliferation, migration and invasion. In conclusion, LncSHANK3/miR-4530/MNX1 axis is a potential mechanism for the treatment of GC.

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