Long Noncoding RNAs in Gastric Cancer: Functions and Clinical Applications

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2016 Mar 2

PMID 26929639

Citations 30

Authors

Jiajun Wang

Jingxu Sun

Jun Wang

Yongxi Song

Peng Gao

Jinxin Shi

Ping Chen

Zhenning Wang

Affiliations

Soon will be listed here.

Abstract

Over the last two decades, genome-wide studies have revealed that only a small fraction of the human genome encodes proteins; long noncoding RNAs (lncRNAs) account for 98% of the total genome. These RNA molecules, which are >200 nt in length, play important roles in diverse biological processes, including the immune response, stem cell pluripotency, cell proliferation, apoptosis, differentiation, invasion, and metastasis by regulating gene expression at the epigenetic, transcriptional, and posttranscriptional levels. However, the detailed molecular mechanisms underlying lncRNA function are only partially understood. Recent studies showed that many lncRNAs are aberrantly expressed in gastric cancer (GC) tissues, gastric juice, plasma, and cells, and these alterations are linked to the occurrence, progression, and outcome of GC. Here, we review the current knowledge of the biological functions and clinical aspects of lncRNAs in GC.

Citing Articles

The effect of LNCRNA SHANK3 on the malignant development of gastric cancer cells by regulating the miR-4530/MNX1.

Zhao L, Xiang Y, Wang J, Shen C, Liu H, Zong Q Transl Oncol. 2024; 46:102000.

PMID: 38852278 PMC: 11220521. DOI: 10.1016/j.tranon.2024.102000.

Gastric Cancer in the Era of Epigenetics.

Christodoulidis G, Koumarelas K, Kouliou M, Thodou E, Samara M Int J Mol Sci. 2024; 25(6).

PMID: 38542354 PMC: 10970362. DOI: 10.3390/ijms25063381.

Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers.

Zabeti Touchaei A, Vahidi S, Samadani A Clin Exp Med. 2024; 24(1):29.

PMID: 38294554 PMC: 10830721. DOI: 10.1007/s10238-023-01260-5.

Long non-coding RNA BC002811 Promotes Gastric Cancer Metastasis by Regulating SOX2 Binding to the Promoter.

Lin X, Li G, Yan X, Fu W, Ruan J, Ding H Int J Biol Sci. 2023; 19(3):967-980.

PMID: 36778127 PMC: 9909995. DOI: 10.7150/ijbs.76407.

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials.

Khan A, Zhang X Bioengineering (Basel). 2022; 9(8).

PMID: 36004931 PMC: 9405066. DOI: 10.3390/bioengineering9080406.

References

Xu Z, Yu Q, Du Y, Yang L, Dong R, Huang L . Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial-mesenchymal transition in gastric cancer. Int J Biol Sci. 2013; 9(6):587-97. PMC: 3708039. DOI: 10.7150/ijbs.6339. View

Perez D, Hoage T, Pritchett J, Ducharme-Smith A, Halling M, Ganapathiraju S . Long, abundantly expressed non-coding transcripts are altered in cancer. Hum Mol Genet. 2007; 17(5):642-55. DOI: 10.1093/hmg/ddm336. View

Zhang E, Kong R, Yin D, You L, Sun M, Han L . Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. Oncotarget. 2014; 5(8):2276-92. PMC: 4039162. DOI: 10.18632/oncotarget.1902. View

Li L, Zhang L, Zhang Y, Zhou F . Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer. Biomed Pharmacother. 2015; 72:109-12. DOI: 10.1016/j.biopha.2015.04.007. View

Li M, Izpisua Belmonte J . Roles for noncoding RNAs in cell-fate determination and regeneration. Nat Struct Mol Biol. 2015; 22(1):2-4. DOI: 10.1038/nsmb.2946. View

Cai H, Chen J, He B, Li Q, Li Y, Gao Y . A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration. Mol Cell Biochem. 2015; 406(1-2):31-41. DOI: 10.1007/s11010-015-2421-3. View

Zhuang Y, Wang X, Nguyen H, Zhuo Y, Cui X, Fewell C . Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen. J Hematol Oncol. 2013; 6:35. PMC: 3655931. DOI: 10.1186/1756-8722-6-35. View

Xu T, Liu X, Xia R, Yin L, Kong R, Chen W . SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer. Oncogene. 2015; 34(45):5648-61. DOI: 10.1038/onc.2015.18. View

Saka M, Morita S, Fukagawa T, Katai H . Present and future status of gastric cancer surgery. Jpn J Clin Oncol. 2011; 41(3):307-13. DOI: 10.1093/jjco/hyq240. View

10.

Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Shoda K . Circulating long non-coding RNAs in plasma of patients with gastric cancer. Anticancer Res. 2013; 33(8):3185-93. View

11.

Zemel S, Bartolomei M, Tilghman S . Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Nat Genet. 1992; 2(1):61-5. DOI: 10.1038/ng0992-61. View

12.

Mei D, Song H, Wang K, Lou Y, Sun W, Liu Z . Up-regulation of SUMO1 pseudogene 3 (SUMO1P3) in gastric cancer and its clinical association. Med Oncol. 2013; 30(4):709. DOI: 10.1007/s12032-013-0709-2. View

13.

Poirier F, Chan C, Timmons P, Robertson E, Evans M, Rigby P . The murine H19 gene is activated during embryonic stem cell differentiation in vitro and at the time of implantation in the developing embryo. Development. 1991; 113(4):1105-14. DOI: 10.1242/dev.113.4.1105. View

14.

Chen F, Tian Y, Pang E, Wang Y, Li L . MALAT2-activated long noncoding RNA indicates a biomarker of poor prognosis in gastric cancer. Cancer Gene Ther. 2015; . DOI: 10.1038/cgt.2015.6. View

15.

Liu L, Yan B, Yang Z, Zhang X, Gu Q, Yue X . ncRuPAR inhibits gastric cancer progression by down-regulating protease-activated receptor-1. Tumour Biol. 2014; 35(8):7821-9. DOI: 10.1007/s13277-014-2042-6. View

16.

Hartgrink H, Jansen E, van Grieken N, van de Velde C . Gastric cancer. Lancet. 2009; 374(9688):477-90. PMC: 4613761. DOI: 10.1016/S0140-6736(09)60617-6. View

17.

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H . The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 2012; 22(9):1775-89. PMC: 3431493. DOI: 10.1101/gr.132159.111. View

18.

Lin X, Yang M, Xia T, Guo J . Increased expression of long noncoding RNA ABHD11-AS1 in gastric cancer and its clinical significance. Med Oncol. 2014; 31(7):42. DOI: 10.1007/s12032-014-0042-4. View

19.

Kondo M, Suzuki H, Ueda R, Osada H, Takagi K, Takahashi T . Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers. Oncogene. 1995; 10(6):1193-8. View

20.

Roobol M, Schroder F, van Leenders G, Hessels D, van den Bergh R, Wolters T . Performance of prostate cancer antigen 3 (PCA3) and prostate-specific antigen in Prescreened men: reproducibility and detection characteristics for prostate cancer patients with high PCA3 scores (≥ 100). Eur Urol. 2010; 58(6):893-9. DOI: 10.1016/j.eururo.2010.09.030. View