Lineage Specification in Glioblastoma is Regulated by METTL7B

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2024 Jun 7

PMID 38848215

Authors

Myrianni Constantinou

James Nicholson

Xinyu Zhang

Eleni Maniati

Sara Lucchini

Gabriel Rosser

Claire Vinel

Jun Wang

Yau Mun Lim

Sebastian Brandner

Sven Nelander

Sara Badodi

Silvia Marino

Affiliations

Soon will be listed here.

Abstract

Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineage specification in glioblastoma, with an impact on both tumor size and invasiveness. Single-cell transcriptomic analysis of these tumors and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B reveal a regulatory role for the gene in the neural stem cell-to-astrocyte differentiation trajectory. Mechanistically, METTL7B downregulates the expression of key neuronal differentiation players, including SALL2, via post-translational modifications of histone marks.

Citing Articles

Advancing Glioblastoma Research with Innovative Brain Organoid-Based Models.

Correia C, Calado S, Matos A, Esteves F, De Sousa-Coelho A, Campinho M Cells. 2025; 14(4).

PMID: 39996764 PMC: 11854129. DOI: 10.3390/cells14040292.

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