Clinical Significance of Ribosomal Protein S15 Expression in Patients with Colorectal Cancer Liver Metastases

Overview

Journal J Hepatobiliary Pancreat Sci

Date 2024 Jun 5

PMID 38838053

Authors

Yoshihiro Sakano

Daijiro Matoba

Takehiro Noda

Shogo Kobayashi

Daisaku Yamada

Yoshito Tomimaru

Hidenori Takahashi

Mamoru Uemura

Yuichiro Doki

Hidetoshi Eguchi

Affiliations

Soon will be listed here.

Abstract

Background: Liver metastasis is the most frequently observed distant metastasis of colorectal cancer, and the residual liver recurrence rate after hepatic resection is still high. To explore the mechanism of liver metastasis to discover potential new treatments, we assessed the relationship between the expression of differentially expressed genes (DEGs) and prognosis in patients with colorectal cancer liver metastasis (CRLM).

Methods: The gene expression dataset was extracted from The Cancer Genome Atlas and the Gene Expression Omnibus. Significance analysis of DEGs between tumor and normal samples of colorectum, liver, and lung was conducted. A total of 80 CRLM patients were studied to assess the expression of RPS15, characteristics, and outcomes. We examined the relationships of RPS15 expression to cell viability and apoptosis in vitro and vivo.

Results: Significance analysis identified 33 DEGs. In our cohorts, the overall survival rates were significantly lower in the high-RPS15-expression group, and high expression of RPS15 was an independent and unfavorable prognostic factor in recurrence-free survival and overall survival. Knockdown of RPS15 expression reduced the proliferative capacity of colorectal cancer cells and increased BAX-induced apoptotic cell death.

Conclusions: RPS15 expression is an independent prognostic factor for CRLM patients and might be a novel therapeutic target for CRLM.

Citing Articles

Comprehensive data of 5085 patients newly diagnosed with colorectal liver metastasis between 2013 and 2017: Fourth report of a nationwide survey in Japan.

Sakamoto K, Beppu T, Honda G, Kotake K, Yamamoto M, Takahashi K J Hepatobiliary Pancreat Sci. 2024; 32(1):26-43.

PMID: 39530296 PMC: 11780304. DOI: 10.1002/jhbp.12078.

Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases.

Sakano Y, Matoba D, Noda T, Kobayashi S, Yamada D, Tomimaru Y J Hepatobiliary Pancreat Sci. 2024; 31(9):611-624.

PMID: 38838053 PMC: 11503462. DOI: 10.1002/jhbp.12012.

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