Imaging Neuroinflammation in Individuals with Substance Use Disorders

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2024 Jun 3

PMID 38828729

Authors

Xinyi Li

Astrid P Ramos-Rolon

Gabriel Kass

Lais S Pereira-Rufino

Naomi Shifman

Zhenhao Shi

Nora D Volkow

Corinde E Wiers

Affiliations

Soon will be listed here.

Abstract

Increasing evidence suggests a role of neuroinflammation in substance use disorders (SUDs). This Review presents findings from neuroimaging studies assessing brain markers of inflammation in vivo in individuals with SUDs. Most studies investigated the translocator protein 18 kDa (TSPO) using PET; neuroimmune markers myo-inositol, choline-containing compounds, and N-acetyl aspartate using magnetic resonance spectroscopy; and fractional anisotropy using MRI. Study findings have contributed to a greater understanding of neuroimmune function in the pathophysiology of SUDs, including its temporal dynamics (i.e., acute versus chronic substance use) and new targets for SUD treatment.

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References

Ende G, Hermann D, Demirakca T, Hoerst M, Tunc-Skarka N, Weber-Fahr W . Loss of control of alcohol use and severity of alcohol dependence in non-treatment-seeking heavy drinkers are related to lower glutamate in frontal white matter. Alcohol Clin Exp Res. 2013; 37(10):1643-9. DOI: 10.1111/acer.12149. View

Grodin E, Nieto S, Meredith L, Burnette E, ONeill J, Alger J . Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. Addict Biol. 2022; 27(4):e13182. PMC: 9888600. DOI: 10.1111/adb.13182. View

Hillmer A, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson R . Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study. J Nucl Med. 2020; 61(8):1200-1204. PMC: 7413239. DOI: 10.2967/jnumed.119.237735. View

Rae C . A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra. Neurochem Res. 2013; 39(1):1-36. DOI: 10.1007/s11064-013-1199-5. View

Brody A, Hubert R, Enoki R, Garcia L, Mamoun M, Okita K . Effect of Cigarette Smoking on a Marker for Neuroinflammation: A [C]DAA1106 Positron Emission Tomography Study. Neuropsychopharmacology. 2017; 42(8):1630-1639. PMC: 5518907. DOI: 10.1038/npp.2017.48. View

Savjani R, Velasquez K, Thompson-Lake D, Baldwin P, Eagleman D, De La Garza 2nd R . Characterizing white matter changes in cigarette smokers via diffusion tensor imaging. Drug Alcohol Depend. 2014; 145:134-42. DOI: 10.1016/j.drugalcdep.2014.10.006. View

Gogliettino A, Potenza M, Yip S . White matter development and tobacco smoking in young adults: A systematic review with recommendations for future research. Drug Alcohol Depend. 2016; 162:26-33. PMC: 4833590. DOI: 10.1016/j.drugalcdep.2016.02.015. View

De Santis S, Bach P, Perez-Cervera L, Cosa-Linan A, Weil G, Vollstadt-Klein S . Microstructural White Matter Alterations in Men With Alcohol Use Disorder and Rats With Excessive Alcohol Consumption During Early Abstinence. JAMA Psychiatry. 2019; 76(7):749-758. PMC: 6583663. DOI: 10.1001/jamapsychiatry.2019.0318. View

Lederer K, Fouche J, Wilson D, Stein D, Uhlmann A . Frontal white matter changes and aggression in methamphetamine dependence. Metab Brain Dis. 2015; 31(1):53-62. DOI: 10.1007/s11011-015-9775-9. View

10.

De Bellis M, Van Voorhees E, Hooper S, Gibler N, Nelson L, Hege S . Diffusion tensor measures of the corpus callosum in adolescents with adolescent onset alcohol use disorders. Alcohol Clin Exp Res. 2008; 32(3):395-404. PMC: 3566638. DOI: 10.1111/j.1530-0277.2007.00603.x. View

11.

Sung Y, Cho S, Hwang J, Kim S, Kim H, Bae S . Relationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: a proton magnetic resonance spectroscopy study. Drug Alcohol Depend. 2006; 88(1):28-35. DOI: 10.1016/j.drugalcdep.2006.09.011. View

12.

Mason G, Petrakis I, de Graaf R, Gueorguieva R, Guidone E, Coric V . Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking. Biol Psychiatry. 2005; 59(1):85-93. DOI: 10.1016/j.biopsych.2005.06.009. View

13.

Zou Y, Murray D, Durazzo T, Schmidt T, Murray T, Meyerhoff D . White matter microstructural correlates of relapse in alcohol dependence. Psychiatry Res Neuroimaging. 2018; 281:92-100. PMC: 6204088. DOI: 10.1016/j.pscychresns.2018.09.004. View

14.

Rupprecht R, Papadopoulos V, Rammes G, Baghai T, Fan J, Akula N . Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov. 2010; 9(12):971-88. DOI: 10.1038/nrd3295. View

15.

Ma X, Qiu Y, Tian J, Wang J, Li S, Zhan W . Aberrant default-mode functional and structural connectivity in heroin-dependent individuals. PLoS One. 2015; 10(4):e0120861. PMC: 4393019. DOI: 10.1371/journal.pone.0120861. View

16.

Grodin E, Bujarski S, Towns B, Burnette E, Nieto S, Lim A . Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial. Transl Psychiatry. 2021; 11(1):355. PMC: 8197758. DOI: 10.1038/s41398-021-01478-5. View

17.

Durazzo T, Meyerhoff D, Mon A, Abe C, Gazdzinski S, Murray D . Chronic Cigarette Smoking in Healthy Middle-Aged Individuals Is Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels. Biol Psychiatry. 2015; 79(6):481-8. PMC: 4600002. DOI: 10.1016/j.biopsych.2015.03.029. View

18.

Heinzerling K, Briones M, Thames A, Hinkin C, Zhu T, Wu Y . Randomized, Placebo-Controlled Trial of Targeting Neuroinflammation with Ibudilast to Treat Methamphetamine Use Disorder. J Neuroimmune Pharmacol. 2019; 15(2):238-248. PMC: 8651052. DOI: 10.1007/s11481-019-09883-w. View

19.

Heckman P, Van Duinen M, Bollen E, Nishi A, Wennogle L, Blokland A . Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications. Int J Neuropsychopharmacol. 2016; 19(10). PMC: 5091819. DOI: 10.1093/ijnp/pyw030. View

20.

Yoder K, Territo P, Hutchins G, Hannestad J, Morris E, Gallezot J . Comparison of standardized uptake values with volume of distribution for quantitation of [(11)C]PBR28 brain uptake. Nucl Med Biol. 2014; 42(3):305-8. PMC: 4329090. DOI: 10.1016/j.nucmedbio.2014.11.003. View