Fischer's Oligopeptide Ratio in Ischemic Hypoxia: Prophylactic Amendment of Sophoretin and Melatonin Supplementation

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2024 Jun 3

PMID 38827802

Authors

Mai O Kadry

Hanaa Mahmoud Ali

Affiliations

Soon will be listed here.

Abstract

The fundamental pathophysiology of ischemic-hypoxia is oxygen depletion. Fischer's ratio is essential for monitoring hypoxia intensity. the current study highlighted the prophylactic role of sophoretin (QRC) and/or melatonin (MLN) versus sodium nitrite (SN) brain hypoxia. Prophylactic treatment with sophoretin and MLN, was preceded with hypoxia-induction via sodium nitrite (60 mg/kg, S.C.). SN decreased hemoglobin (Hb), elevated , HSP-70, IL-6 and TNF-α. Sophoretin and/or MLN restored the ameliorated inflammatory biomarkers, modulated norepinephrine, dopamine, serotonin and gamma-aminobutyric acid (GABA). Similarly, single-cell gel electrophoresis (SCGE or COMET) DNA damage assay confirmed this finding. Treatment via sophoretin and MLN was the most effective therapy for improving sodium nitrite-induced brain injury.

Citing Articles

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