The Correlation Between Selenium Intake and Lung Function in Asthmatic People: a Cross-sectional Study

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2024 Jun 3

PMID 38826577

Authors

Hejun Jiang

Guijun Yang

Jing Chen

Shuhua Yuan

Jinhong Wu

Jing Zhang

Lei Zhang

Jiajun Yuan

Jilei Lin

Jiande Chen

Yong Yin

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to examine the correlation between selenium intake and lung function in asthmatic people.

Methods: A total of 4,541 individuals in the US National Health and Nutrition Examination Survey (NHANES) were included in this study. Multivariate linear regression, variance inflation factor, restricted cubic splines and quantile regression were used to analyze the relationship between Se intake and lung function. We divided selenium intake into four levels based on quartiles: Q1: Se ≤ 76.75 mcg/d; Q2: 76.75-105.1 mcg/d; Q3: 105.1-137.65 mcg/d; and Q4: Se ≥137.65 mcg/d.

Results: Asthma was negatively associated with the Ratio of Forced Expiratory Volume 1st Second to Forced Vital Capacity (FEV1/FVC) (β = -0.04, 95% CI: -0.06 to -0.02) and FEV1 (β = -215, 95% CI: -340 to -90). Se intake was positively associated with Forced Expiratory Volume 1st Second (FEV1) (β =3.30 95% CI: 2.60 to 4.00) and Forced Vital Capacity (FVC) (β =4.30, 95% CI: 3.50 to 5.10). In asthmatic individuals, the positive effects of Se intake on FVC were enhanced with increasing Se intake, while the positive effects of Se intake on FEV1 varied less dramatically. High Se intake (Q4 level, above 137.65 mcg/d) improved FVC (β = 353, 95% CI: 80 to 626) and FEV1 (β = 543, 95% CI: 118 to 969) in asthmatic patients compared to low Se intake (Q1 level, below 76.75 mcg/d). At the Q2 level (76.75-105.1 mcg/d) and Q4 level (Se ≥137.65 mcg/d) of Se intake, the correlation between FEV1 and asthma disappeared.

Conclusion: Our research has revealed a positive correlation between selenium intake and lung function in asthma patients and the strength of this positive correlation is related to the amount of selenium intake. We recommend that asthma patients consume 137.65 mcg to 200 mcg of selenium daily to improve pulmonary function while avoiding the adverse effects of selenium on the human body.

Citing Articles

The Link Between Dysbiosis, Inflammation, Oxidative Stress, and Asthma-The Role of Probiotics, Prebiotics, and Antioxidants.

Kleniewska P, Pawliczak R Nutrients. 2025; 17(1.

PMID: 39796449 PMC: 11722634. DOI: 10.3390/nu17010016.

Association of systemic immune biomarkers with metabolic dysfunction-associated steatotic liver disease: a cross-sectional study of NHANES 2007-2018.

Wang Y, Chen S, Tian C, Wang Q, Yang Z, Che W Front Nutr. 2024; 11:1415484.

PMID: 39296508 PMC: 11408230. DOI: 10.3389/fnut.2024.1415484.

References

Prasad K, Selvaraj K . Biogenic synthesis of selenium nanoparticles and their effect on As(III)-induced toxicity on human lymphocytes. Biol Trace Elem Res. 2014; 157(3):275-83. DOI: 10.1007/s12011-014-9891-0. View

Pryor W, Prier D, Church D . Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ Health Perspect. 1983; 47:345-55. PMC: 1569403. DOI: 10.1289/ehp.8347345. View

Teng Y, Sun P, Zhang J, Yu R, Bai J, Yao X . Hydrogen peroxide in exhaled breath condensate in patients with asthma: a promising biomarker?. Chest. 2011; 140(1):108-116. DOI: 10.1378/chest.10-2816. View

Vinceti M, Crespi C, Malagoli C, Del Giovane C, Krogh V . Friend or foe? The current epidemiologic evidence on selenium and human cancer risk. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2013; 31(4):305-41. PMC: 3827666. DOI: 10.1080/10590501.2013.844757. View

Huang Z, Rose A, Hoffmann P . The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2011; 16(7):705-43. PMC: 3277928. DOI: 10.1089/ars.2011.4145. View

Zhu Z, Jiang W, Ganther H, Ip C, Thompson H . In vitro effects of Se-allylselenocysteine and Se-propylselenocysteine on cell growth, DNA integrity, and apoptosis. Biochem Pharmacol. 2000; 60(10):1467-73. DOI: 10.1016/s0006-2952(00)00461-5. View

Cardoso B, Hare D, Bush A, Li Q, Fowler C, Masters C . Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). J Alzheimers Dis. 2017; 57(1):183-193. DOI: 10.3233/JAD-160622. View

Roman M, Jitaru P, Barbante C . Selenium biochemistry and its role for human health. Metallomics. 2013; 6(1):25-54. DOI: 10.1039/c3mt00185g. View

Mostofa M, Hossain M, Siddiqui M, Fujita M, Tran L . Phenotypical, physiological and biochemical analyses provide insight into selenium-induced phytotoxicity in rice plants. Chemosphere. 2017; 178:212-223. DOI: 10.1016/j.chemosphere.2017.03.046. View

10.

Ganas K, Loukides S, Papatheodorou G, Panagou P, Kalogeropoulos N . Total nitrite/nitrate in expired breath condensate of patients with asthma. Respir Med. 2001; 95(8):649-54. DOI: 10.1053/rmed.2001.1117. View

11.

Steinbrenner H, Speckmann B, Klotz L . Selenoproteins: Antioxidant selenoenzymes and beyond. Arch Biochem Biophys. 2016; 595:113-9. DOI: 10.1016/j.abb.2015.06.024. View

12.

Karadogan B, Beyaz S, Gelincik A, Buyukozturk S, Arda N . Evaluation of oxidative stress biomarkers and antioxidant parameters in allergic asthma patients with different level of asthma control. J Asthma. 2020; 59(4):663-672. DOI: 10.1080/02770903.2020.1870129. View

13.

Ventura M, Melo M, Carrilho F . Selenium and Thyroid Disease: From Pathophysiology to Treatment. Int J Endocrinol. 2017; 2017:1297658. PMC: 5307254. DOI: 10.1155/2017/1297658. View

14.

Kohrle J . Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes. 2015; 22(5):392-401. DOI: 10.1097/MED.0000000000000190. View

15.

Hoffmann F, Hashimoto A, Shafer L, Dow S, Berry M, Hoffmann P . Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols. J Nutr. 2010; 140(6):1155-61. PMC: 2869499. DOI: 10.3945/jn.109.120725. View

16.

Dharmage S, Perret J, Custovic A . Epidemiology of Asthma in Children and Adults. Front Pediatr. 2019; 7:246. PMC: 6591438. DOI: 10.3389/fped.2019.00246. View

17.

Hornos Carneiro M, Rhoden C, Amantea S, Barbosa Jr F . Low concentrations of selenium and zinc in nails are associated with childhood asthma. Biol Trace Elem Res. 2011; 144(1-3):244-52. DOI: 10.1007/s12011-011-9080-3. View

18.

Estevez A, Morgan K, Szewczyk N, Gems D, Estevez M . The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans. Neurotoxicology. 2014; 41:28-43. PMC: 3979119. DOI: 10.1016/j.neuro.2013.12.012. View

19.

Qujeq D, Hidari B, Bijani K, Shirdel H . Glutathione peroxidase activity and serum selenium concentration in intrinsic asthmatic patients. Clin Chem Lab Med. 2003; 41(2):200-2. DOI: 10.1515/CCLM.2003.032. View

20.

Cardoso B, Roberts B, Bush A, Hare D . Selenium, selenoproteins and neurodegenerative diseases. Metallomics. 2015; 7(8):1213-28. DOI: 10.1039/c5mt00075k. View