Spatially Resolved Tissue Imaging to Analyze the Tumor Immune Microenvironment: Beyond Cell-type Densities

Overview

Journal J Immunother Cancer

Specialties Allergy & Immunology
Oncology
Pharmacology

Date 2024 May 31

PMID 38821717

Authors

Alvaro Lopez Janeiro

Eduardo Miraval Wong

Daniel Jimenez-Sanchez

Carlos Ortiz de Solorzano

Maria D Lozano

Alvaro Teijeira

Kurt A Schalper

Ignacio Melero

Carlos E de Andrea

Affiliations

Soon will be listed here.

Abstract

Introduction: The tissue immune microenvironment is associated with key aspects of tumor biology. The interaction between the immune system and cancer cells has predictive and prognostic potential across different tumor types. Spatially resolved tissue-based technologies allowed researchers to simultaneously quantify different immune populations in tumor samples. However, bare quantification fails to harness the spatial nature of tissue-based technologies. Tumor-immune interactions are associated with specific spatial patterns that can be measured. In recent years, several computational tools have been developed to increase our understanding of these spatial patterns.

Topics Covered: In this review, we cover standard techniques as well as new advances in the field of spatial analysis of the immune microenvironment. We focused on marker quantification, spatial intratumor heterogeneity analysis, cell‒cell spatial interaction studies and neighborhood analyses.

Citing Articles

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