Gene Expression Signatures in Blood from a West African Sepsis Cohort Define Host Response Phenotypes

Overview

Journal Nat Commun

Specialty Biology

Date 2024 May 30

PMID 38816375

Authors

Josh G Chenoweth

Carlo Colantuoni

Deborah A Striegel

Pavol Genzor

Joost Brandsma

Paul W Blair

Subramaniam Krishnan

Elizabeth Chiyka

Mehran Fazli

Rittal Mehta

Michael Considine

Leslie Cope

Audrey C Knight

Anissa Elayadi

Anne Fox

Ronna Hertzano

Andrew G Letizia

Alex Owusu-Ofori

Isaac Boakye

Albert A Aduboffour

Daniel Ansong

Eno Biney

George Oduro

Kevin L Schully

Danielle V Clark

Affiliations

Soon will be listed here.

Abstract

Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patterns that describe cell type-specific molecular phenotypes including a dysregulated myeloid compartment shared between sepsis and COVID-19. The gene expression signatures reported here define a landscape of host response to sepsis that supports interventions via targeting immunophenotypes to improve outcomes.

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