Antiangiogenic Potential of an Olive Oil Extract: Insights from a Proteomic Study

Overview

Journal J Agric Food Chem

Specialties Chemistry
Nutritional Sciences

Date 2024 May 29

PMID 38809962

Authors

Ana Dacil Marrero

Casimiro Cardenas

Laura Castilla

Juan Ortega-Vidal

Ana R Quesada

Beatriz Martinez-Poveda

Miguel Angel Medina

Affiliations

Soon will be listed here.

Abstract

Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects on vascular health remain relatively unexplored. In this study, we examined the impact of a "picual" EVOO extract from Jaén, Spain, on endothelial cells. Proteomic analysis revealed the modulation of angiogenesis-related processes. In subsequent in vitro experiments, the EVOO extract inhibited endothelial cell migration, adhesion, invasion, ECM degradation, and tube formation while inducing apoptosis. These results provide robust evidence of the extract's antiangiogenic potential. Our findings highlight the potential of EVOO extracts in mitigating angiogenesis-related pathologies, such as cancer, macular degeneration, and diabetic retinopathy.

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